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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/59649
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dc.creatorLaura Dominguetept_BR
dc.creatorPaulo Limapt_BR
dc.creatorIsabela Nunespt_BR
dc.creatorDenise Sande Santospt_BR
dc.creatorUbiraci Gomes de Paula Lanapt_BR
dc.creatorIvanildo Marrielpt_BR
dc.creatorJacqueline Aparecida Takahashipt_BR
dc.date.accessioned2023-10-18T20:46:29Z-
dc.date.available2023-10-18T20:46:29Z-
dc.date.issued2019-
dc.citation.volume75pt_BR
dc.citation.spage331pt_BR
dc.citation.epage336pt_BR
dc.identifier.doihttps://doi.org/10.3303/CET1975056pt_BR
dc.identifier.issn2283-9216pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/59649-
dc.description.resumoFungal metabolites with antioxidant and acetylcholinesterase inhibitory activities can be developed as food supplements helpful for treatment of neurodegenerative diseases, like Alzheimer's disease. Fungal biosynthesis depends on the expression of several enzymes that can change chromatin’s conformation, provoking activation or silencing of gene transcription. In this sense, the use of epigenetic modulators, able to alter chromatin’s conformation, has been a modern technique used to induce the expression of silenced genes in fungi. In the present study the metabolic profile and the antioxidant and anti-acetylcholinesterase activities of the extracts of Penicillium flavigenum (PF) and P. tanzanicum (PT) grown in the presence of epigenetic modulators were analyzed. The fungi were grown in liquid media, with or without (control) the epigenetic modulators azacytidine (AZA), hydralazine (HYDRA), procainamide (PRO), suberoyl hydroxamic acid (SAHA) and sodium butyrate (BUT) (500 μM). The modulators changed the expression of exogenous metabolites produced by the fungi with overexpression of some compounds in comparison to the controls, according to the HPLC chromatographic profiles. The treatment PF-SAHA presented the higher content of total phenolic compounds (27.86 mg GAE/g) (together with PF-HYDRA and PF-BUT) and the higher total antioxidant content (25.70 mg AAE/g). Besides, PF-SAHA and PF-PRO extracts presented higher antiacetylcholinesterase activity compared to others extracts. AZA was one of the most effective treatments for increasing expression of metabolites with antioxidant activity by P. tanzanicum in at least half of the assays. Treatments PT-AZA, PT-HYDRA and PT-BUT showed statistically similar anti-acetylcholinesterase activity, which were superior to the activity of the fungal control (15%). In overall, fermentative conditions using PFSAHA and PF-PRO showed to be the most favorable to produce new bioactive metabolites to be used as food supplements for palliative treatment or prevention of Alzheimer’s disease, while complete cure is not possible so far.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofChemical Engineering Transactionspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCiência e Tecnologia de Alimentospt_BR
dc.subjectQuímicapt_BR
dc.subject.otherCiência e Tecnologia de Alimentospt_BR
dc.subject.otherQuímicapt_BR
dc.titleEpigenetic-Induced Production of Promising Food Supplements Ingredients with Antioxidant and Anti-Acetylcholinesterase Activitiespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.aidic.it/cet/19/75/056.pdfpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8831-1609pt_BR
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