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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/59661
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dc.creatorGeisa Gabriela da Silvapt_BR
dc.creatorLúcia Pinheiro Santos Pimentapt_BR
dc.creatorJúlio Onésio Ferreira Melopt_BR
dc.creatorHenrique de Oliveira Prata Mendonçapt_BR
dc.creatorRodinei Augustipt_BR
dc.creatorJacqueline Aparecida Takahashipt_BR
dc.date.accessioned2023-10-18T20:55:15Z-
dc.date.available2023-10-18T20:55:15Z-
dc.date.issued2022-03-15-
dc.citation.volume27pt_BR
dc.citation.issue6pt_BR
dc.citation.spage1892pt_BR
dc.citation.epage18pt_BR
dc.identifier.doihttps://doi.org/10.3390/molecules27061892pt_BR
dc.identifier.issn1420-3049pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/59661-
dc.description.resumoAvocado (Persea americana) is a widely consumed fruit and a rich source of nutrients and phytochemicals. Its industrial processing generates peels and seeds which represent 30% of the fruit. Environmental issues related to these wastes are rapidly increasing and likely to double, according to expected avocado production. Therefore, this work aimed to evaluate the potential of hexane and ethanolic peel (PEL-H, PEL-ET) and seed (SED-H, SED-ET) extracts from avocado as sources of neuroprotective compounds. Minerals, total phenol (TPC), total flavonoid (TF), and lipid contents were determined by absorption spectroscopy and gas chromatography. In addition, phytochemicals were putatively identified by paper spray mass spectrometry (PSMS). The extracts were good sources of Ca, Mg, Fe, Zn, ω-6 linoleic acid, and flavonoids. Moreover, fifty-five metabolites were detected in the extracts, consisting mainly of phenolic acids, flavonoids, and alkaloids. The in vitro antioxidant capacity (FRAP and DPPH), acetylcholinesterase inhibition, and in vivo neuroprotective capacity were evaluated. PEL-ET was the best acetylcholinesterase inhibitor, with no significant difference (p > 0.05) compared to the control eserine, and it showed neither preventive nor regenerative effect in the neuroprotection assay. SED-ET demonstrated a significant protective effect compared to the control, suggesting neuroprotection against rotenone-induced neurological damage.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofMoleculespt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAvocado biomasspt_BR
dc.subjectAlzheimer’s diseasept_BR
dc.subjectNeuroprotective effectpt_BR
dc.subjectAvocado seedpt_BR
dc.subjectAvocado peelpt_BR
dc.subjectPaper spray mass spectrometrypt_BR
dc.subject.otherBiomassapt_BR
dc.subject.otherAlzheimer, Doença dept_BR
dc.subject.otherAbacatept_BR
dc.titlePhytochemicals of Avocado Residues as Potential Acetylcholinesterase Inhibitors, Antioxidants, and Neuroprotective Agentspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.mdpi.com/1420-3049/27/6/1892pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5596-8698pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8384-6877pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7483-0942pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9448-9518pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8831-1609pt_BR
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