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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/59785
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dc.creatorJuliana Kern de Moraespt_BR
dc.creatorVivian Petersen Wagnerpt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorGleyson Kleber do Amaral Silvapt_BR
dc.creatorPablo Agustin Vargaspt_BR
dc.creatorManoela Domingues Martinspt_BR
dc.creatorCaroline Brunetto de Fariaspt_BR
dc.creatorEmily Ferreira Salles Pilarpt_BR
dc.creatorLauro Gregianinpt_BR
dc.creatorRafael Roeslerpt_BR
dc.date.accessioned2023-10-19T23:54:39Z-
dc.date.available2023-10-19T23:54:39Z-
dc.date.issued2019-
dc.citation.issue8pt_BR
dc.citation.spage1925pt_BR
dc.citation.epage1936pt_BR
dc.identifier.doihttps://doi.org/10.1111/odi.13190pt_BR
dc.identifier.issn1354523Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/59785-
dc.description.resumoObjectives: To evaluate the expression of brain-derived neurotrophic factor (BDNF), its tyrosine kinase receptor B (TrkB), and two downstream targets of this pathway, Akt and ribosomal protein S6 (RPS6), in normal oral mucosa (NOM), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC) and correlate this expression with OSCC patients' outcomes, cell senescence, and "stemness" profile. Materials and methods: Ten cases of NOM, 32 OL, and 72 primary OSCC were included. Immunohistochemical analysis for BDNF, TrkB, p-TrkB, p-Akt, and p-RPS6 was performed. Cell senescence and stemness profile of OSCC were evaluated through p16 and BMI-1 immunohistochemical expression, respectively. The slides were scanned into high-resolution images and quantified through digital analysis. Results: Oral squamous cell carcinoma presented increased expression of BDNF/TrkB/Akt pathway compared to NOM and OL. OSCC diagnosed in advanced clinical stages presented an upregulation of BDNF and p-TrkB. BDNF and p-Akt were identified as predictors of poor disease-specific survival. The increase in stemness profile was correlated with a decrease in p-TrkB and p-Akt expression. Conclusions: BDNF/TrkB/Akt pathway is significantly increased in malignant cells from OSCC. Moreover, BDNF and Akt represent biomarkers capable to predict a poor prognosis of OSCC patients.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofOral Diseasespt_BR
dc.rightsAcesso Restritopt_BR
dc.subject.otherBiomarkerspt_BR
dc.subject.otherHead and neck neoplasmspt_BR
dc.subject.otherImmunohistochemistrypt_BR
dc.subject.otherPredictive value of testspt_BR
dc.subject.otherPrognosispt_BR
dc.subject.otherBrain-derived neurotrophic factorpt_BR
dc.subject.otherReceptor, trkBpt_BR
dc.subject.otherSquamous cell carcinoma of head and neckpt_BR
dc.subject.otherProteinspt_BR
dc.subject.otherMouth mucosapt_BR
dc.subject.otherLeukoplakia, oralpt_BR
dc.subject.otherSurvivalpt_BR
dc.subject.otherAgingpt_BR
dc.titleActivation of BDNF/trkB/Akt pathway is associated with aggressiveness and unfavorable survival in oral squamous cell carcinomapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/odi.13190pt_BR
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