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http://hdl.handle.net/1843/59950
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DC Field | Value | Language |
---|---|---|
dc.creator | Celeste Sánchez-Romero | pt_BR |
dc.creator | Hélder Antônio Rebelo Pontes | pt_BR |
dc.creator | Flávia Sirotheau Corrêa Pontes | pt_BR |
dc.creator | André Caroli Rocha | pt_BR |
dc.creator | Román Carlos | pt_BR |
dc.creator | Javier Rendon | pt_BR |
dc.creator | Oslei Paes de Almeida | pt_BR |
dc.creator | Felipe Paiva Fonseca | pt_BR |
dc.date.accessioned | 2023-10-24T18:45:51Z | - |
dc.date.available | 2023-10-24T18:45:51Z | - |
dc.date.issued | 2018-08 | - |
dc.citation.volume | 126 | pt_BR |
dc.citation.issue | 2 | pt_BR |
dc.citation.spage | 152 | pt_BR |
dc.citation.epage | 164 | pt_BR |
dc.identifier.doi | https://www.sciencedirect.com/science/article/pii/S2212440318300464?via%3Dihub | pt_BR |
dc.identifier.issn | 22124403 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/1843/59950 | - |
dc.description.resumo | Objective: Our objective was to describe the clinicopathologic and immunohistochemical features of acute lymphoblastic leukemia/lymphoma (ALL/LBL) of the oral and maxillofacial region (OMF). Study design: Cases diagnosed as ALL/LBL of the OMF region were retrieved from the files of 2 Brazilian and 1 Guatemalan oral pathology services from 2005 to 2017. Microscopic and immunohistochemical features of each case were reviewed and fully described, and clinical data were retrieved from the pathology reports. Results: During the period considered, 6 cases were identified. Male patients were the most affected (4:2), with a mean age of 19 years old. The mandible was involved in 2 cases, the maxilla in 2, the cheek mucosa in 1, and the parotid gland in 1. Painful swelling was the most common presentation, and 3 patients also had systemic complaints. Microscopically, tumors revealed solid infiltrations of small to medium-sized immature cells. "Puzzle-like" and "starry-sky" patterns were observed, and "single lane" growth was also identified. Immunohistochemically, 2 cases were diagnosed as T-cell ALL/LBL with the leukocyte common antigen (LCA)+/cCD3+/CD79 a+focal/CD20-/PAX5-/CD99+/CD34-/CD10+/terminal deoxynucleotidyl transferase (TdT)+ phenotype and 4 as B-cell ALL/LBL with the LCA+/CD3-/CD20-/CD79 a+/CD10+/CD34 variable/TdT+ predominant phenotype. The Ki67 index ranged from 80% to 99%. Conclusion: OMF ALL/LBL is rare, but its microscopic features and immunohistochemical profiles CD3+or CD79 a+/CD10+/CD34+variable/CD99+/TdT+ contribute to the correct diagnosis. | pt_BR |
dc.language | eng | pt_BR |
dc.publisher | Universidade Federal de Minas Gerais | pt_BR |
dc.publisher.country | Brasil | pt_BR |
dc.publisher.department | FAO - DEPARTAMENTO DE CLÍNICA | pt_BR |
dc.publisher.initials | UFMG | pt_BR |
dc.relation.ispartof | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology | pt_BR |
dc.rights | Acesso Restrito | pt_BR |
dc.subject | acesso restrito Acute lymphoblastic leukemia/lymphoma of the oral and maxillofacial region busca dia 11 do 09 2023 assunto leucemia, linfoma fao clínica | pt_BR |
dc.subject.other | Leukemia | pt_BR |
dc.subject.other | Lymphoma | pt_BR |
dc.subject.other | Immunohistochemistry | pt_BR |
dc.subject.other | Pathology, oral | pt_BR |
dc.title | Acute lymphoblastic leukemia/lymphoma of the oral and maxillofacial region | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.url.externa | https://doi.org/10.1016/j.oooo.2018.01.010 | pt_BR |
Appears in Collections: | Artigo de Periódico |
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