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Type:	Artigo de Periódico
Title:	Oral and maxillofacial manifestations of chronic kidney disease-mineral and bone disorder: a multicenter retrospective study
Authors:	Flávia Sirotheau Corrêa Pontes Wladimir Gushiken de Campos Milena Coelho Fernandes Caldato Regina Matsunaga Martin Felipe Paiva Fonseca Hélder Antônio Rebelo Pontes Márcio Ajudarte Lopes Lucas Lacerda de Souza Diogo Rezende Alan Roger dos Santos-Silva Jacks Jorge Wagner Gomes da Silva Fábio Ramôa Pires André Caroli Rocha
Abstract:	Objective: To describe the oral and maxillofacial manifestations of patients diagnosed with chronic kidney disease-mineral and bone disorders. Study design: Over a 13-year period, clinicopathologic data of patients diagnosed with CKD-MBD who had oral and maxillofacial alterations were retrieved from the files of 4 Brazilian institutions. Data included clinical, radiographic, microscopic, and biochemical findings; treatment employed; and follow-up status. Results: Twenty-one cases were identified, with 13 patients diagnosed as brown tumor of hyperparathyroidism (BTH) and 8 as osteitis fibrosa/renal osteodystrophy (OF/RO) (4 of them clinically consistent with Sagliker syndrome). The mean age was 32.7 years, and the mandible was the most affected site (42.8%). OF/RO had an ill-defined "ground glass" radiographic appearance, and BTH produced well-defined radiolucent images. Biochemically the following mean values were obtained: parathormone 1511.07 pg/mL, calcium 9.25 mg/dL, phosphorus 5.19 mg/dL, alkaline phosphatase 941.55 U/L, urea 125.42 mg/dL, and creatinine 7.14 mg/dL. Treatment comprised vitamin D and calcium intake, parathyroidectomy, hemodialysis, renal transplantation, and local surgery. During follow-up, 5 patients with BTH were free of lesions, whereas 2 affected by OF/RO/Sagliker syndrome died. Conclusions: Oral and maxillofacial manifestations of BTH and OF/RO are uncommon, but they can be associated with an important life-threatening scenario
Subject:	Chronic kidney disease-mineral and bone disorder Mouth Maxilla Face Mandible Disease
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	FAO - DEPARTAMENTO DE CLÍNICA
Rights:	Acesso Restrito
metadata.dc.identifier.doi:	https://doi.org/10.1016/j.oooo.2017.09.011
URI:	http://hdl.handle.net/1843/60026
Issue Date:	Jan-2018
metadata.dc.url.externa:	https://www.sciencedirect.com/science/article/pii/S2212440317310672?via%3Dihub
metadata.dc.relation.ispartof:	Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Appears in Collections:	Artigo de Periódico

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