1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/60397
Full metadata record
DC FieldValueLanguage
dc.creatorMatheus Vilardo Lóes Moreirapt_BR
dc.creatorIngeborg Maria Langohrpt_BR
dc.creatorMarina Rios de Araújo Campospt_BR
dc.creatorEnio Ferreirapt_BR
dc.creatorBárbara Carvalhopt_BR
dc.creatorGuilherme Reis Blumept_BR
dc.creatorFabiano Montiani-Ferreirapt_BR
dc.creatorRoselene Eccopt_BR
dc.date.accessioned2023-10-31T21:35:58Z-
dc.date.available2023-10-31T21:35:58Z-
dc.date.issued2022-02-05-
dc.citation.volume8pt_BR
dc.citation.issue3pt_BR
dc.citation.spage1036pt_BR
dc.citation.epage1048pt_BR
dc.identifier.doihttps://doi.org/10.1002/vms3.752pt_BR
dc.identifier.issn2053-1095pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60397-
dc.description.resumoObjective Gross, histopathological, and immunohistochemical characteristics of uveal melanocytic neoplasms in dogs and cats were investigated. Samples Thirty-two enucleated globes with uveal melanocytic neoplasms, 27 from dogs and 5 from cats, were examined. Procedures Morphological characteristics of uveal melanocytic neoplasms in dogs and cats were evaluated with anti-PNL2, anti-Melan-A, anti-Ki-67, anti-caspase-3, and anti-BAP1 immunomarkers. Statistical analysis was performed to compare canine melanocytomas and melanomas. Results The 32 uveal neoplasms were classified as melanocytomas (19/27 in dogs) or melanomas (8/27 in dogs, 5/5 in cats). Most tumours (84%) were located in the anterior uvea. Neoplastic cells were classified as epithelioid, spindle-shaped, mixed, or special type (balloon and signet ring cells). The percentage of cells with melanin, melanin concentration within cells, anisocytosis and anisokaryosis, mitotic count, lymphocytic inflammation, necrosis, vascular invasion, and glaucoma were also characterized. Anisocytosis, percentage of neoplastic cells with melanin, mitotic count, and indices (proliferation and apoptotic) varied significantly between canine uveal melanomas and melanocytomas; in general, melanomas had greater cell variability, were less pigmented, and had a higher mitotic count. The melanocytic origin of the neoplasms was confirmed by positive anti-PNL2 immunolabelling (29/32) and positive anti-Melan-A immunolabelling (3/32). In canine uveal melanomas, anisocytosis and anisokaryosis correlated with less pigmentation and minimal pigmentation correlated with a high percentage of immunolabelling for caspase-3. Conclusions Uveal melanocytomas were more common in dogs, and uveal melanomas were more frequent in cats. Anisocytosis, percentage of neoplastic cells with melanin, and mitotic count are important histologic characteristics of malignancy to evaluate in uveal melanocytic neoplasms. The proliferation and apoptotic indices are relevant when comparing malignant tumours with benign tumours.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIApt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.departmentVET - DEPARTAMENTO DE CLÍNICA E CIRURGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofVeterinary Medicine and Sciencept_BR
dc.rightsAcesso Abertopt_BR
dc.subjectApoptosispt_BR
dc.subjectGlobept_BR
dc.subjectImmunohistochemistrypt_BR
dc.subjectMelanocytomapt_BR
dc.subjectMelanomapt_BR
dc.subjectTumour aggressiveness factorspt_BR
dc.subject.otherMedicina Veterináriapt_BR
dc.subject.otherTumorespt_BR
dc.subject.otherGatospt_BR
dc.subject.otherMelanomapt_BR
dc.subject.otherApoptosept_BR
dc.titleCanine and feline uveal melanocytic tumours: Histologic and immunohistochemical characteristics of 32 casespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1002/vms3.752pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0173-3524pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7366-4391pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8052-5389pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
File Description SizeFormat 
Canine and feline uveal melanocytic tumours_ Histologic and immunohistochemical characteristics of 32 cases.pdf2.1 MBAdobe PDFView/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.