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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/60449
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dc.creatorVictor Costapt_BR
dc.creatorEduardo Rodrigues Fregnanipt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorFábio Abreu Alvespt_BR
dc.creatorClóvis Antonio Lopes Pintopt_BR
dc.creatorEstela Kaminagakura Tangopt_BR
dc.date.accessioned2023-11-01T20:56:49Z-
dc.date.available2023-11-01T20:56:49Z-
dc.date.issued2018-05-
dc.citation.volume125pt_BR
dc.citation.issue5pt_BR
dc.citation.spage454pt_BR
dc.citation.epage458pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2018.02.014pt_BR
dc.identifier.issn22124403pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60449-
dc.description.resumoObjective: The aim of this study was to investigate alterations in the EGFR gene and its protein expression for a better understanding of the biologic behavior of ameloblastoma. Study design: Twenty-five samples of ameloblastoma were selected, and dual-color fluorescence in situ hybridization assay was performed. The results of the assay and immunohistochemistry reaction for EGFR and Ki67 were associated with clinicopathologic features and recurrence. Results: All analyzed cases presented disomy without any gene polysomy or amplification. With regard to EGFR immunoexpression, 3 cases (12%) were considered negative, and 22 (88%) were positive, of which 13 (52%) were weak and 9 (36%) were strong. All samples presented low positivity for Ki67. There was no association between EGFR expression and clinicopathologic features or recurrence (P > .05). In some cases, EGFR immunoexpression was observed without gene amplification. Conclusions: Ameloblastoma development, progression, or recurrence does not appear to be related to EGFR amplification or polysomy.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Oral Radiologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectbusca dia 20 do 09 2023 acesso restrito fao clinica assunto Genes, erbB-1 gene EGFRpt_BR
dc.subjectbusca dia 20 do 09 2023 acesso restrito fao clinica assunto Genes, erbB-1 gene EGFRpt_BR
dc.subject.otherGenespt_BR
dc.subject.otherAmeloblastomapt_BR
dc.subject.otherProteinspt_BR
dc.titleEGFR is not amplified in ameloblastomapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S2212440318300853?via%3Dihubpt_BR
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