Preparo e administração de inibidores de bombas de prótons via sonda enteral: uma revisão da literatura

Abstract

Introduction:The administration of drugs via enteral tube is frequent in clinical practice and presents several challenges, especially for some classes of drugs, such as proton pump inhibitors (PPI).Aim:The present study aims to gather studies that approach information on the preparation and administration of PPIs via enteral tube.Materials and methods:A literature review was carried out in Pubmed and Lilacs databases, using the descriptors and free terms referring to the topic. Results: A total of 1.583 articles were retrieved, which 13 articles were included because they approached techniques for preparation and administration of PPIs via enteral tube. Discussion:Several procedures were tested for the preparation and administration of PPIs via enteral tube, such as solubilization in water, sodium bicarbonate solution or acidic juices. The parenteral route has also been suggested as an alternative route of administration in some studies.Conclusion:This review compiled relevant technical information on PPI administration via enteral tube in order to assist healthcare professionals in selecting the appropriate PPI and preferred route of administration. However, most of the findings emphasize that, for the selection of the best administration procedures, the reality of each institution and the clinical profile of the patient must be taken into account. Considering that several ways of preparing and administering PPIs were studied and most of them did not present consistent results, it is necessary to conduct more studies in this area of knowledge, which concentration onthe effective and safe use of PPIs via enteral tube.