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http://hdl.handle.net/1843/60505| Type: | Artigo de Periódico |
| Title: | Metabolomics for prediction of hypertension in pregnancy: a systematic review and meta-analysis protocol |
| Authors: | Jussara de Souza Mayrink Novais Debora f Leite m. l. Costa José g. Cecatti |
| Abstract: | Introduction: Hypertension is a very important cause of maternal morbidity and mortality worldwide, despite efforts on prevention. The lack of a tool to provide effective and early prediction of hypertension for a high- risk group may contribute to improving maternal and fetal outcomes. Metabolomics has figured out as a promised technology to contribute to the improvement of hypertension in pregnancy prediction.Methods and analysis: Our primary outcome is hypertensive disorders of pregnancy. A detailed systematic literature search will be performed in electronic databases PubMed, EMBASE, Scopus, Web of Science, Latin America and Caribbean Health Sciences Literature, Scientific Electronic Library Online, Health Technology Assessment and Database of Abstracts of Reviews of Effects using controlled terms ‘pre- eclampsia’, ‘hypertensive disorders’, ‘metabolomics’ and ‘prediction’ (and their variations). Studies from the latest 20 years will be included, except case reports, reviews, cross- sectional studies, letter to editors, expert opinions, commentaries papers or non human research. If possible, we will perform a meta analysis. Two peer- reviewers will independently perform the search and in cases of discordance, a third reviewer will be consulted.Ethics and dissemination As a systematic review, ethics approval is not required. The results of this review will present the current use and performance of metabolomics for predicting gestational hypertension. Such data could potentially guide future studies and interventions to improve existing prediction models. |
| Subject: | Hypertension Maternal Mortality Metabolomics |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | MED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | 10.1136/bmjopen-2020-040652 |
| URI: | http://hdl.handle.net/1843/60505 |
| Issue Date: | 2020 |
| metadata.dc.url.externa: | https://bmjopen.bmj.com/content/10/12/e040652 |
| metadata.dc.relation.ispartof: | BMJ Open |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Metabolomics for prediction of pdfa.pdf | 269.35 kB | Adobe PDF | View/Open |
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