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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/60506
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dc.creatorJussara de Souza Mayrink Novaispt_BR
dc.creatorDebora f Leitept_BR
dc.creatorGuilherme m Nobregapt_BR
dc.creatorMaria Laura Costapt_BR
dc.creatorJose Guilherme Cecattipt_BR
dc.date.accessioned2023-11-06T20:15:41Z-
dc.date.available2023-11-06T20:15:41Z-
dc.date.issued2022-
dc.citation.volume12pt_BR
dc.citation.issuee054697pt_BR
dc.citation.spage1pt_BR
dc.citation.epage19pt_BR
dc.identifier.doi10.1136/bmjopen-2021-054697pt_BR
dc.identifier.issn20446055pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60506-
dc.description.resumoObjective:To determine the accuracy of metabolomics in predicting hypertensive disorders in pregnancy.Design Systematic review of observational studies.Data sources and study eligibility criteria An electronic literature search was performed in June 2019 and February 2022. Two researchers independently selected studies published between 1998 and 2022 on metabolomic techniques applied to predict the condition; subsequently, they extracted data and performed quality assessment. Discrepancies were dealt with a third reviewer. The primary outcome was pre- eclampsia. Cohort or case–control studies were eligible when maternal samples were taken before diagnosis of the hypertensive disorder.Study appraisal and synthesis methods Data on study design, maternal characteristics, how hypertension was diagnosed, metabolomics details and metabolites, and accuracy were independently extracted by two authors.Results Among 4613 initially identified studies on metabolomics, 68 were read in full text and 32 articles were included. Studies were excluded due to duplicated data, study design or lack of identification of metabolites. Metabolomics was applied mainly in the second trimester; the most common technique was liquid- chromatography coupled to mass spectrometry. Among the 122 different metabolites found, there were 23 amino acids and 21 fatty acids. Most of the metabolites were involved with ammonia recycling; amino acid metabolism; arachidonic acid metabolism; lipid transport, metabolism and peroxidation; fatty acid metabolism; cell signalling; galactose metabolism; nucleotide sugars metabolism; lactose degradation; and glycerolipid metabolism. Only citrate was a common metabolite for prediction of early onset and late- onset pre- eclampsia. Vitamin D was the only metabolite in common for pre- eclampsia and gestational hypertension prediction. Meta- analysis was not performed due to lack of appropriate standardised data.Conclusions and implications: Metabolite signatures may contribute to further insights into the pathogenesis of pre- eclampsia and support screening tests. Nevertheless, it is mandatory to validate such methods in larger studies with a heterogeneous population to ascertain the potential for their use in clinical practice.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBMJ Open-
dc.rightsAcesso Abertopt_BR
dc.subjectPregnancypt_BR
dc.subjecthypertensionpt_BR
dc.subjectMetabolomicspt_BR
dc.subject.otherPregnancypt_BR
dc.subject.otherHypertensionpt_BR
dc.subject.otherMetabolomicspt_BR
dc.titlePrediction of pregnancy-related hypertensive disorders using metabolomics: a systematic reviewpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://pubmed.ncbi.nlm.nih.gov/35470187/pt_BR
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