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Use este identificador para citar ou linkar para este item: http://hdl.handle.net/1843/60508
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Campo DCValorIdioma
dc.creatorFernanda Alvarenga Lima Barrosopt_BR
dc.creatorEnio Ferreirapt_BR
dc.creatorFlaviano Dos Santos Martinspt_BR
dc.creatorMariana Martins Drumondpt_BR
dc.creatorPamela Mancha-agrestipt_BR
dc.creatorAlexander Birbrairpt_BR
dc.creatorDebmalya Barhpt_BR
dc.creatorVasco Azevedopt_BR
dc.creatorLuís Cláudio Lima de Jesuspt_BR
dc.creatorTales Fernando da Silvapt_BR
dc.creatorViviane Lima Batistapt_BR
dc.creatorJuliana Lagunapt_BR
dc.creatorNina Dias Coelho-Rochapt_BR
dc.creatorKátia Duarte Vitalpt_BR
dc.creatorSimone Odília Antunes Fernandespt_BR
dc.creatorValbert Nascimento Cardosopt_BR
dc.date.accessioned2023-11-06T20:29:56Z-
dc.date.available2023-11-06T20:29:56Z-
dc.date.issued2022-
dc.citation.volume13pt_BR
dc.citation.spage858036pt_BR
dc.identifier.doihttps://doi.org/10.3389/fmicb.2022.858036pt_BR
dc.identifier.issn1664-302Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60508-
dc.description.resumoIntestinal mucositis promoted by the use of anticancer drugs is characterized by ulcerative inflammation of the intestinal mucosa, a debilitating side effect in cancer patients undergoing treatment. Probiotics are a potential therapeutic option to alleviate intestinal mucositis due to their effects on epithelial barrier integrity and anti-inflammatory modulation. This study investigated the health-promoting impact of Lactobacillus delbrueckii CIDCA 133 in modulating inflammatory and epithelial barrier markers to protect the intestinal mucosa from 5-fluorouracil-induced epithelial damage. L. delbrueckii CIDCA 133 consumption ameliorated small intestine shortening, inflammatory cell infiltration, intestinal permeability, villus atrophy, and goblet cell count, improving the intestinal mucosa architecture and its function in treated mice. Upregulation of Muc2, Cldn1, Hp, F11r, and Il10, and downregulation of markers involved in NF-κB signaling pathway activation (Tlr2, Tlr4, Nfkb1, Il6, and Il1b) were observed at the mRNA level. This work suggests a beneficial role of L. delbrueckii strain CIDCA 133 on intestinal damage induced by 5-FU chemotherapy through modulation of inflammatory pathways and improvement of epithelial barrier function.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentFARMACIA - FACULDADE DE FARMACIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofFrontiers in Microbiologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectMucositept_BR
dc.subjectTumorespt_BR
dc.subjectProbióticospt_BR
dc.subjectTratamento Farmacológicopt_BR
dc.subject.otherMucositept_BR
dc.subject.otherTumorespt_BR
dc.subject.otherProbióticospt_BR
dc.subject.otherTratamento Farmacológicopt_BR
dc.titleLactobacillus delbrueckii CIDCA 133 Ameliorates Chemotherapy-Induced Mucositis by Modulating Epithelial Barrier and TLR2/4/Myd88/NF-κB Signaling Pathwaypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.frontiersin.org/articles/10.3389/fmicb.2022.858036/fullpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1835-0303pt_BR
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