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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/60509
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dc.creatorFlávia Aguiarpt_BR
dc.creatorPaula Rhana Queiroz Araújopt_BR
dc.creatorEnrrico Bloisept_BR
dc.creatorAndreia Laura Prates Rodriguespt_BR
dc.creatorEnio Ferreirapt_BR
dc.date.accessioned2023-11-06T20:30:27Z-
dc.date.available2023-11-06T20:30:27Z-
dc.date.issued2022-08-10-
dc.citation.volume5pt_BR
dc.citation.issue1pt_BR
dc.citation.spage16pt_BR
dc.citation.epage8pt_BR
dc.identifier.doihttps://doi.org/10.1186/s42047-022-00117-7pt_BR
dc.identifier.issn2520-8454pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60509-
dc.description.resumoBackground Intracellular Ca2+ levels can modulate several cellular functions, including proliferation and other processes found altered in neoplastic cells. Helping to maintain Ca2+ homeostasis, L-type voltage-dependent Ca2+ channels had its expression identified in neoplasias, including breast cancer. Invasive breast carcinoma of no special type, the most common classification of breast cancer, has ductal hyperplasia and ductal carcinoma in situ as its possible non-obligate precursors. This channel’s role in breast cancer development from these precursors has not been investigated. Evaluate protein expression and subcellular localization of CaV1.1, CaV1.2, and CaV1.3 in mammary epithelium without alteration and neoplastic and non-neoplastic ductal proliferative lesions through immunohistochemistry was the aim of this investigation. Methods In the present study, CaV1.1, CaV1.2, and CaV1.3 protein expression was evaluated by immunohistochemistry in breast without alteration and in proliferative non-neoplastic and neoplastic ductal epithelial lesions of the human breast. Results It was observed that CaV1.3 presented a reduction in nuclear expression at neoplastic lesions, in addition to an increase in cytoplasmic CaV1.1 expression. The analyses of membrane immunostaining showed that CaV1.2 and CaV1.3 had an increase of expression as the lesions progressed in the stages leading to invasive carcinomas. Conclusions Changes in protein expression and subcellular localization of these channels during the progression stages indicate that they may be involved in neoplastic transformation.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIApt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofSurgical and Experimental Pathologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectBreast cancerpt_BR
dc.subjectDuctal hyperplasiapt_BR
dc.subjectCarcinoma in situpt_BR
dc.subjectL-type voltage-dependent Ca2+ channelpt_BR
dc.subjectLTCCpt_BR
dc.subjectNeoplastic transformationpt_BR
dc.subject.otherNeoplasias da Mamapt_BR
dc.subject.otherHiperplasiapt_BR
dc.subject.otherCarcinoma in situpt_BR
dc.titleL-type voltage-dependent Ca2+ channels expression involved in pre-neoplastic transformation of breast cancerpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://surgexppathol.biomedcentral.com/articles/10.1186/s42047-022-00117-7pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-1835-0303pt_BR
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