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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/60510
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dc.creatorViviane Lima Batistapt_BR
dc.creatorÊnio Ferreirapt_BR
dc.creatorJuliana Guimarães Lagunapt_BR
dc.creatorLuiz Carlos Júnior Alcântarapt_BR
dc.creatorVasco Ariston de Carvalho Azevedopt_BR
dc.creatorLuís Cláudio Lima de Jesuspt_BR
dc.creatorLaísa Macedo Tavarespt_BR
dc.creatorFernanda Alvarenga Lima Barrosopt_BR
dc.creatorLucas Jorge da Silva Fernandespt_BR
dc.creatorAndria Dos Santos Freitaspt_BR
dc.creatorMonique Ferrary Américopt_BR
dc.creatorMariana Martins Drumondpt_BR
dc.creatorPamela Mancha-agrestipt_BR
dc.date.accessioned2023-11-06T20:30:50Z-
dc.date.available2023-11-06T20:30:50Z-
dc.date.issued2022-07-14-
dc.citation.volume10pt_BR
dc.citation.issue7pt_BR
dc.citation.spage1418pt_BR
dc.citation.epage18pt_BR
dc.identifier.doihttps://doi.org/10.3390/microorganisms10071418pt_BR
dc.identifier.issn2076-2607pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60510-
dc.description.resumoIntestinal mucositis is a commonly reported side effect in oncology practice. Probiotics are considered an excellent alternative therapeutic approach to this debilitating condition; however, there are safety questions regarding the viable consumption of probiotics in clinical practice due to the risks of systemic infections, especially in immune-compromised patients. The use of heat-killed or cell-free supernatants derived from probiotic strains has been evaluated to minimize these adverse effects. Thus, this work evaluated the anti-inflammatory properties of paraprobiotics (heat-killed) and postbiotics (cell-free supernatant) of the probiotic Lactobacillus delbrueckii CIDCA 133 strain in a mouse model of 5-Fluorouracil drug-induced mucositis. Administration of paraprobiotics and postbiotics reduced the neutrophil cells infiltrating into the small intestinal mucosa and ameliorated the intestinal epithelium architecture damaged by 5-FU. These ameliorative effects were associated with a downregulation of inflammatory markers (Tlr2, Nfkb1, Il12, Il17a, Il1b, Tnf), and upregulation of immunoregulatory Il10 cytokine and the epithelial barrier markers Ocln, Cldn1, 2, 5, Hp and Muc2. Thus, heat-killed L. delbrueckii CIDCA 133 and supernatants derived from this strain were shown to be effective in reducing 5-FU-induced inflammatory damage, demonstrating them to be an alternative approach to the problems arising from the use of live beneficial microorganisms in clinical practice.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIApt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofMicroorganismspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectMucositispt_BR
dc.subjectChemotherapypt_BR
dc.subjectIntestinal damagept_BR
dc.subjectHeat-killed bacteriapt_BR
dc.subjectCell-free supernatantpt_BR
dc.subjectImmunomodulationpt_BR
dc.subject.otherMicrobiologiapt_BR
dc.subject.otherMucositept_BR
dc.subject.otherTratamento Farmacológicopt_BR
dc.subject.otherIntestinospt_BR
dc.subject.otherImunomodulaçãopt_BR
dc.titleParaprobiotics and Postbiotics of Lactobacillus delbrueckii CIDCA 133 Mitigate 5-FU-Induced Intestinal Inflammationpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.mdpi.com/2076-2607/10/7/1418pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1835-0303pt_BR
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