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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/60521
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dc.creatorDanuza Montijo Dinizpt_BR
dc.creatorCélio Jose Castro Juniorpt_BR
dc.creatorCarlos Malamutpt_BR
dc.creatorMarina Rios Araújopt_BR
dc.creatorAndrea Vidal Ferreirapt_BR
dc.creatorJuliana Figueira Silvapt_BR
dc.creatorMarta do Nascimento Cordeiropt_BR
dc.creatorMarcia Helena Borgespt_BR
dc.creatorMarco Aurelio Romano Silvapt_BR
dc.creatorMarcus Vinicius Gomezpt_BR
dc.date.accessioned2023-11-06T20:41:18Z-
dc.date.available2023-11-06T20:41:18Z-
dc.date.issued2022-
dc.citation.volume8pt_BR
dc.citation.spage770471pt_BR
dc.citation.epage10pt_BR
dc.identifier.doihttps://doi.org/10.3389/fmolb.2021.770471pt_BR
dc.identifier.issn2296-889Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60521-
dc.description.resumoPreclinical evidence suggests the potential of Phα1β, a toxin obtained from the venom of spider Phoneutria nigriventer, as a new analgesic drug. Molecular brain imaging techniques have afforded exciting opportunities to examine brain processes in clinical pain conditions. This paper aims to study the brain regions involved in the analgesic effects of Phα1β compared with Morphine, in a model of acute pain induced by formalin in Sprague Dawley rats. We used 18F-fluorodeoxyglucose as a metabolic radiotracer to perform brain imaging of rats pretreated with Phα1β or Morphine in a model of acute inflammatory pain caused by intraplantar injection of formalin. The rats’ hind paw’s formalin stimulation resulted in a brain metabolic increase at the bilateral motor cortex, visual cortex, somatosensory cortex, thalamus, and cingulate cortex.In rats treated with Phα1β, selective inhibition of unilateral motor cortex and cingulate cortex was observed. Morphine treatment leads to small and selective inhibition at the bilateral amygdala striatum and accumbens. Our results indicate that the analgesic effect of Phα1β and Morphine possesses a differential profile of central processing in the pain state.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTALpt_BR
dc.publisher.departmentMEDICINA - FACULDADE DE MEDICINApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofFrontiers in Molecular Biosciencespt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectP. E. Tpt_BR
dc.subjectPainpt_BR
dc.subjectMorphinept_BR
dc.subjectPhα1βpt_BR
dc.subjectBrainpt_BR
dc.subject18F-FDGpt_BR
dc.subject.otherDorpt_BR
dc.subject.otherMorfinapt_BR
dc.subject.otherEncéfalopt_BR
dc.titleMapping of Brain Activity in the Analgesia Induced by Phα1β and Morphinept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.frontiersin.org/articles/10.3389/fmolb.2021.770471/fullpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6558-4639pt_BR
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