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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/60527
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dc.creatorFernanda Ludolfpt_BR
dc.creatorFernanda Fonseca Ramospt_BR
dc.creatorEduardo Antonio Ferraz Coelhopt_BR
dc.creatorFlávia F. Bagnopt_BR
dc.creatorJoão A. Oliveira-da-Silvapt_BR
dc.creatorThiago A. R. Reispt_BR
dc.creatorMyron Christodoulidespt_BR
dc.creatorPaula F. Vassallopt_BR
dc.creatorCecilia G. Ravettipt_BR
dc.creatorVandack Nobrept_BR
dc.creatorFlavio G. da Fonsecapt_BR
dc.date.accessioned2023-11-06T20:47:11Z-
dc.date.available2023-11-06T20:47:11Z-
dc.date.issued2022-05-13-
dc.citation.volume8pt_BR
dc.citation.issue19pt_BR
dc.citation.spageeabn7424pt_BR
dc.citation.epage3pt_BR
dc.identifier.doihttps://doi.org/10.1126/sciadv.abn7424pt_BR
dc.identifier.issn2571-9262pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60527-
dc.description.resumoSerum-based ELISA (enzyme-linked immunosorbent assay) has been widely used to detect anti–severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies. However, to date, no study has investigated patient urine as a biological sample to detect SARS-CoV-2 virus-specific antibodies. An in-house urine-based ELISA was developed using recombinant SARS-CoV-2 nucleocapsid protein. The presence of SARS-CoV-2 antibodies in urine was established, with 94% sensitivity and 100% specificity for the detection of anti–SARS-CoV-2 antibodies with the urine-based ELISA and 88% sensitivity and 100% specificity with a paired serum-based ELISA. The urine-based ELISA that detects anti–SARS-CoV-2 antibodies is a noninvasive method with potential application as a facile COVID-19 immunodiagnostic platform, which can be used to report the extent of exposure at the population level and/or to assess the risk of infection at the individual level.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIALpt_BR
dc.publisher.departmentMEDICINA - FACULDADE DE MEDICINApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofScience Advancespt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectDiagnósticopt_BR
dc.subjectCOVID-19pt_BR
dc.subjectUrinapt_BR
dc.subject.otherImunologiapt_BR
dc.subject.otherBiotecnologiapt_BR
dc.subject.otherCOVID-19pt_BR
dc.subject.otherUrinapt_BR
dc.subject.otherDiagnósticopt_BR
dc.titleDetecting anti–SARS-CoV-2 antibodies in urine samples: A noninvasive and sensitive way to assay COVID-19 immune conversionpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.science.org/doi/10.1126/sciadv.abn7424pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3357-9816pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7852-0300pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1578-6678pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9663-4731pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7531-0607pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7922-0422pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1416-8694pt_BR
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