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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/60542
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dc.creatorMárcio Leandro Ribeiro de Souzapt_BR
dc.creatorAnn Kristine Jansenpt_BR
dc.creatorLuiz Oswaldo c Rodriguespt_BR
dc.creatorDarlene Vilelapt_BR
dc.creatorAdriana Kakehasipt_BR
dc.creatorAline Stangherlin Martinspt_BR
dc.creatorJuliana Ferreira de Souzapt_BR
dc.creatorNilton Alves Resendept_BR
dc.date.accessioned2023-11-06T21:41:57Z-
dc.date.available2023-11-06T21:41:57Z-
dc.date.issued2020-
dc.citation.volume66pt_BR
dc.citation.issue5pt_BR
dc.citation.spage666pt_BR
dc.citation.epage672pt_BR
dc.identifier.doi10.1590/1806-9282.66.5.666pt_BR
dc.identifier.issn01044230pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60542-
dc.description.resumoNeurofibromatosis type 1 (NF1) is an autosomal dominant genetic disease characterized by multisystem involvement including low bone mineral density (BMD).OBJECTIVE: To assess the bone phenotype of individuals with NF1 and verify its associationwith nutrient intake.METHODS: Twenty-six adults with NF1 underwent bone phenotype assessments using dual-energy X-ray absorptiometry (DXA) andfood intake evaluations. They were compared to 26 unaffected matched control patients. Weight, height, and waist circumference(WC) were measured. DXA provided total body, spine, and hip BMDs and bone mineral content (BMC) for all patients. Food intake was evaluated for energy, macro- and micro-nutrients.RESULTS: Height (1.68 ± 0.1; 1.61 ± 0.1 cm; P = 0.003) and BMC (2.3 ± 0.4; 2.0 ± 0.5 kg; P = 0.046) were lower in the NF1 group. Individuals with NF1 also presented lower total body and spine BMDs (g/cm2) (1.1 ± 0.1, 1.0 ± 0.1, P = 0.036; 1.0 ± 0.1, 0.9 ± 0.1; P = 0.015,respectively). The frequency of total body bone mass below the expected level for patients’ ages was higher in the NF1 group (7.7%;34.6%, P = 0.016). There were no differences in energy consumption. No correlations between BMC and BMD with nutrient intake were observed in the NF1 group.CONCLUSIONS: The NF1 group presented lower BMCs and BMDs. Although a lower consumption of calcium, iron, and vitamin A, and a higher intake of sodium and omega-6 were observed, there was no relationship between bone phenotype and nutrient intake.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentENF - DEPARTAMENTO DE ENFERMAGEM APLICADApt_BR
dc.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃOpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE APARELHO LOCOMOTORpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofRevista da Associação Médica Brasileira-
dc.rightsAcesso Abertopt_BR
dc.subjectneurofibromatosis type 1pt_BR
dc.subjectBonept_BR
dc.subjectNutrientpt_BR
dc.subjectFood intakept_BR
dc.subjectNutritionpt_BR
dc.subject.otherNeurofibromatosis 1pt_BR
dc.subject.otherEatingpt_BR
dc.subject.otherNutritional Requirementspt_BR
dc.subject.otherNutrientspt_BR
dc.titleReduced bone mineral content and density in neurofibromatosis type 1 and its association with nutrient intakept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttp://dx.doi.org/10.1590/1806-9282.66.5.666pt_BR
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