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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/60548
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dc.creatorCarla Dayana Durães Abreupt_BR
dc.creatorBruna Viana Caldaspt_BR
dc.creatorGuilherme Henrique Mendes Ribeiropt_BR
dc.creatorCharles Martins Aguilarpt_BR
dc.creatorLucyana Conceição Fariaspt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorMaria Beatriz Abreu Glóriapt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.date.accessioned2023-11-07T10:15:44Z-
dc.date.available2023-11-07T10:15:44Z-
dc.date.issued2022-
dc.citation.volume22pt_BR
dc.citation.spage1pt_BR
dc.citation.epage9pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.phanu.2022.100316pt_BR
dc.identifier.issn2213-4344pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60548-
dc.description.resumoBackground: Lifestyle modifications have increased the consumption of ultra-processed foods, fat, sugar, and salt worldwide and also decreased dietary fiber due to reduced legume, grain, and vegetable intake. Ultimately, the contemporary food intake profile has increased the incidence of obesity and chronic inflammatory diseases. Probiotic dietary supplementation is a viable health option. Methods: Male Swiss mice were fed with two diets for four weeks: standard and standard +Inulin. The serum biochemistry data, histology, and inflammatory-related genes’ mRNA expression in adipose tissue were analyzed. Results: The primary results showed that inulin dietary supplementation decreased the Toll-like receptor 4 transmembrane protein gene (TLR4) expression and interleukin 6 (IL6) in the epididymal adipose tissue, resulting in decreased adipocyte hypertrophy. The high-density lipoprotein (HDL) was increased and TGP enzymes (related to liver injury risk) were decreased also improving insulin sensitivity. Conclusion: The present study revealed that inulin supplementation could improve the onset of chronic inflammation-related markers in adipose tissue indicating that inulin is a natural anti-inflammatory alternative. Data Availability Statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.rightsAcesso Restritopt_BR
dc.subject.otherPrebióticospt_BR
dc.subject.otherNutriçãopt_BR
dc.subject.otherTecido adiposopt_BR
dc.subject.otherInflamaçãopt_BR
dc.subject.otherSíndrome metabólicapt_BR
dc.titleInulin prebiotic dietary supplementation improves metabolic parameters by reducing the Toll-like receptor 4 transmembrane protein gene and interleukin 6 expression in adipose tissuept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S2213434422000299pt_BR
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