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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/60641
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dc.creatorBarbhara Mota Marinhopt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.creatorVictor Hugo Dantas Guimarãespt_BR
dc.creatorJaciara Neves Sousapt_BR
dc.creatorDaniel Silva Moraespt_BR
dc.creatorEmisael Stênio Batista Gomespt_BR
dc.creatorClaudia Regina Vieirapt_BR
dc.creatorSidnei Tavares dos Reispt_BR
dc.creatorTheles de Oliveira Costapt_BR
dc.creatorLucyana Conceição Fariaspt_BR
dc.date.accessioned2023-11-08T13:46:56Z-
dc.date.available2023-11-08T13:46:56Z-
dc.date.issued2022-
dc.citation.volume2pt_BR
dc.citation.spage1pt_BR
dc.citation.epage11pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.phyplu.2021.100154pt_BR
dc.identifier.issn2667-0313pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60641-
dc.description.resumoBackground: Lychnophora ericoides Mart. (Asteraceae) is a Brazilian plant commonly used in folk medicine to treat pain and inflammation by topical administration. In recent years, this medicine has begun to be used orally. However, no study concerning its toxicity profile has been reported. Objective: The study evaluates the potential toxicity of the ethanolic extract from leaves of the Lychnophora ericoides, through the methods of acute and sub-acute oral administration in mice. Method: An acute toxicity study was performed according to the Organization for Economic Cooperation and Development protocol (OECD 423). A single extract dose of 50, 300, and 2000 mg/kg (n =3/group) was administered orally to female Swiss mice. For subacute toxicity, the protocol OECD 407 was followed. Doses of 50, 300, and 500 mg/kg (n =10/group) of the extract were administered daily to Swiss mice of both sexes for 28 days. Abnormal behavior, muscle strength, toxic symptoms, weight, and death were observed when assessing toxicity. Biochemical analysis, hematological analysis, macroscopic examination, and histopathological examination of several organs were conducted at the end of the treatment period. Results: In acute and subacute toxicity, the extract did not produce mortality. The acute toxicity study revealed alterations in the behavioral test and histopathological changes in the liver, kidney, lung, and spleen. The subacute oral toxicity test showed changes in hematologic and biochemical parameters. Histopathological examination of liver, kidney, spleen, lung, and heart indicated degenerative characteristics with inflammatory infiltrates focus. Conclusion: The study results suggest that oral use of Lychnophora ericoides leaves extract should be performed with caution in low doses in both single and repeated administrations.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPhytomedicine Plus-
dc.rightsAcesso Abertopt_BR
dc.subject.otherArnicapt_BR
dc.subject.otherToxicidade agudapt_BR
dc.subject.otherCerradospt_BR
dc.titleBrazilian cerrado plant (arnica) Lychnophora ericoides Mart. (Asteraceae) toxicity characterization in micept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S2667031321001366#pt_BR
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