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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/60709
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dc.creatorJanaina Ribeiro Oliveirapt_BR
dc.creatorAndré Luiz Senna Guimarãespt_BR
dc.creatorLucyana Conceição Fariaspt_BR
dc.creatorFernanda Steffenspt_BR
dc.creatorFernando Ribeiro Oliveirapt_BR
dc.creatorSergio Henrique Sousa Santospt_BR
dc.creatorAmanda Souto Machadopt_BR
dc.creatorDeborah de Farias Lelispt_BR
dc.creatorVictor Hugo Dantas Guimarãespt_BR
dc.creatorLuis Paulo Oliveirapt_BR
dc.creatorSidnei Tavares Reispt_BR
dc.creatorTheles Oliveira Costapt_BR
dc.creatorClaudia Regina Vieirapt_BR
dc.creatorAlfredo Mauricio Batista de Paulapt_BR
dc.date.accessioned2023-11-09T15:21:22Z-
dc.date.available2023-11-09T15:21:22Z-
dc.date.issued2022-
dc.citation.volume32pt_BR
dc.citation.spage86pt_BR
dc.citation.epage98pt_BR
dc.identifier.doihttps://doi.org/10.1007/s43450-021-00225-7pt_BR
dc.identifier.issn0102-695Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60709-
dc.description.resumoThe present study evaluated the efects of natural and artifcial knitted fabrics functionalized with Cordia curassavica (Jacq.) Roem. & Schult., Boraginaceae, in the skin wound healing process induced in mice. C57BL/6 male mouse wounds were treated as follows: polylactic acid fber; polylactic acid fber + C. curassavica oil; cotton; and cotton + C. curassavica oil. The wound closure kinetics, histological analysis, and fbronectin mRNA expression were evaluated after 3, 5, 7, and 14 days of treatment. The wound closure kinetics area under the curve analysis evidenced the polylactic acid fber + oil treatment accelerating the wound closure as compared to other groups (cotton: 541.7 ± 37.73; cotton + oil: 720.4 ± 27.88; polylactic acid fber: 536.8 ± 33.89; polylactic acid fber + oil: 945.7 ± 33.52). The skin wounds treated with functionalized fabrics showed a proper wound healing resolution, normal granulation tissue architecture and cell infltrate, a lower number of mastocytes, a higher collagen deposition, and increased fbronectin mRNA expression levels. In summary, we report for the frst time that the polylactic acid fber accelerates the wound healing process, an efect potentialized by the C. curassavica volatile oil. These fndings point to the polylactic acid fber + oil as an important alternative therapeutic approach to improve wound healing treatment.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofRevista Brasileira de Farmacognosia-
dc.rightsAcesso Restritopt_BR
dc.subject.otherCicatrização de feridaspt_BR
dc.subject.otherCurapt_BR
dc.subject.otherMatéria médica vegetalpt_BR
dc.subject.otherPlantas medicinaispt_BR
dc.titleNatural and artificial knitted fabrics functionalized with Cordia curassavica accelerate excisional wound healing in micept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s43450-021-00225-7pt_BR
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