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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/60755
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dc.creatorCaroline Pereiradominguetipt_BR
dc.creatorJéssica a. Fuzattopt_BR
dc.creatorRodrigo Bastos Fóscolopt_BR
dc.creatorJanice s. Reispt_BR
dc.creatorLuci m. Dussept_BR
dc.creatorMaria Das Graças Carvalhopt_BR
dc.creatorKarina b. Gomespt_BR
dc.creatorAna Paula Fernandespt_BR
dc.date.accessioned2023-11-09T22:24:30Z-
dc.date.available2023-11-09T22:24:30Z-
dc.date.issued2016-
dc.citation.volume62pt_BR
dc.citation.issue1pt_BR
dc.citation.spage27pt_BR
dc.citation.epage33pt_BR
dc.identifier.doi10.1016/j.cca.2016.05.011pt_BR
dc.identifier.issn00098981pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60755-
dc.description.resumoObjective: This study aimed to evaluate the association between different renal biomarkers with D-Dimer levels in diabetes mellitus (DM1) patients group classified as: low D-Dimer levels (< 318 ng/mL), which included first and second D-Dimer tertiles, and high D-Dimer levels (≥ 318 ng/mL), which included third D-Dimer tertile. Materials and methods: D-Dimer and cystatin C were measured by ELISA. Creatinine and urea were determined by enzymatic method. Estimated glomerular filtration rate (eGFR) was calculated using CKD-EPI equation. Albuminuria was assessed by immunoturbidimetry. Presence of renal disease was evaluated using each renal biomarker: creatinine, urea, cystatin C, eGFR and albuminuria. Bivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels and odds ratio was calculated. After, multivariate logistic regression analysis was performed to assess which renal biomarkers are associated with high D-Dimer levels (after adjusting for sex and age) and odds ratio was calculated. Results: Cystatin C presented a better association [OR of 9.8 (3.8–25.5)] with high D-Dimer levels than albuminuria, creatinine, eGFR and urea [OR of 5.3 (2.2–12.9), 8.4 (2.5–25.4), 9.1 (2.6–31.4) and 3.5 (1.4–8.4), respectively] after adjusting for sex and age. All biomarkers showed a good association with D-Dimer levels, and consequently, with hypercoagulability status, and cystatin C showed the best association among them. Conclusion: Therefore, cystatin C might be useful to detect patients with incipient diabetic kidney disease that present an increased risk of cardiovascular disease, contributing to an early adoption of reno and cardioprotective therapiespt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofArchives of Endocrinology and Metabolism-
dc.rightsAcesso Abertopt_BR
dc.subjectD-Dimerpt_BR
dc.subjecttype 1 diabetes mellituspt_BR
dc.subjectCystatin Cpt_BR
dc.subjectCreatininept_BR
dc.subjectAlbuminuriapt_BR
dc.subject.otherDiabetes Mellitus, Type 1pt_BR
dc.subject.otherCreatininept_BR
dc.subject.otherCystatin Cpt_BR
dc.subject.otherAlbuminuriapt_BR
dc.titleAssociation between von willebrand factor, disintegrin and metalloproteinase with thrombospondin type 1 motif member 13, d-dimer and cystatin c levels with retinopathy in type 1 diabetes mellituspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://doi.org/10.20945/2359-3997000000003pt_BR
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