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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/60823
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dc.creatorLuiz Ronaldo Albertipt_BR
dc.creatorLeonardo de Souza Vasconcellospt_BR
dc.creatorAndy Petroianupt_BR
dc.date.accessioned2023-11-10T21:30:42Z-
dc.date.available2023-11-10T21:30:42Z-
dc.date.issued2021-
dc.citation.volume36pt_BR
dc.citation.issue4pt_BR
dc.citation.spage1pt_BR
dc.citation.epage5pt_BR
dc.identifier.doi10.1590/ACB360402pt_BR
dc.identifier.issn01028650pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60823-
dc.description.resumoPurpose: To assess the influence of prolonged cyclosporine use on the macro- and microscopic morphology of the spleen. Methods: 16 adult rabbits were divided into two groups (n = 8): group 1 – a placebo group, which was followed-up over a period of nine months; group 2 – which had taken an oral dose of cyclosporine (10 mg·kg–1·day–1) over nine months. At the end of this period, the splenic histoarchitecture of all animals was evaluated and the splenic corpuscles were measured. Results: The spleens of the first group presented normal characteristics and dimensions. The second group, however, had a reduction in all dimensions and its tissue texture had become soft. The white pulp and the perivascular sheath had become reduced in size and the number of lymphoid follicles had also fallen (p = 0.002), manifesting less splenic corpuscles (p = 0.0012) and lymphocyte nuclear pigments (p = 0.03). Conclusion: Prolonged use of cyclosporine reduces the spleen size, transforming it into a soft organ associated with a decrease in white pulp, perivascular sheath, lymphoid follicles and nuclear pigments in rabbits.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTARpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofActa Cirúrgica Brasileira-
dc.rightsAcesso Abertopt_BR
dc.subjectCyclosporinept_BR
dc.subjectmorphologypt_BR
dc.subjectHistologypt_BR
dc.subjectImmunologypt_BR
dc.subjectRabbitspt_BR
dc.subject.otherCyclosporinept_BR
dc.subject.otherRabbitspt_BR
dc.titleCyclosporine reduces the spleen dimensions in rabbitspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttp://www.scielo.br/pdf/acb/v36n4/1678-2674-acb-36-4-e360402.pdfpt_BR
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