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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/60893
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dc.creatorPaulo a. Fariapt_BR
dc.creatorBruna m. de sá Pereirapt_BR
dc.creatorRafaela Montalvão de Azevedopt_BR
dc.creatorJoaquim Caetano de Aguirre Netopt_BR
dc.creatorClarice Franco Menezespt_BR
dc.creatorKarla Emilia de sa Rodriguespt_BR
dc.creatorBeatriz de Camargopt_BR
dc.creatorMariana Maschiettopt_BR
dc.date.accessioned2023-11-13T20:09:57Z-
dc.date.available2023-11-13T20:09:57Z-
dc.date.issued2019-
dc.citation.volume65pt_BR
dc.citation.issue12pt_BR
dc.citation.spage1496pt_BR
dc.citation.epage1501pt_BR
dc.identifier.doi10.1590/1806-9282.65.12.1496pt_BR
dc.identifier.issn01044230pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60893-
dc.description.resumoChildhood renal tumors account for ~7% of all childhood cancers, and most cases are embryonic Wilms’ tumors (WT). Children with WT are usually treated by either COG or SIOP. The later treats the children using preoperative chemotherapy, but both have around 90% of overall survival in five years. WT is a genetically heterogeneous group with a low prevalence of known somatic alterations. Only around 30% of the cases present mutation in known genes, and there is a relatively high degree of intra-tumor genetic heterogeneity (ITGH). Besides potentially having an impact on the clinical outcome of patients, ITGH may interfere with the search for molecular markers that are prospectively being tested by COG and SIOP. In this review, we present the proposal of the current UMBRELLA SIOP Study 2017/Brazilian Renal Tumor Group that requires the multi-sampling collection of each tumor to better evaluate possible molecular markers, as well as to understand WT biologypt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofRevista da Associação Médica Brasileira-
dc.rightsAcesso Abertopt_BR
dc.subjectWilms tumorpt_BR
dc.subjectBiomarkerspt_BR
dc.subjectGenetic Heterogeneitypt_BR
dc.subject.otherWilms tumorpt_BR
dc.subject.otherBiomarkerspt_BR
dc.subject.otherGenetic Heterogeneitypt_BR
dc.titleIntra-tumor genetic heterogeneity in wilms? tumor samplespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://doi.org/10.1590/1806-9282.65.12.1496pt_BR
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