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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/60972
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dc.creatorAlicia-Rumayor Piñapt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorFlávia-Sirotheau-Corrêa Pontespt_BR
dc.creatorHélder Antônio Rebelo Pontespt_BR
dc.creatorFábio-Ramôa Pirespt_BR
dc.creatorAdalberto-Mosqueda Taylorpt_BR
dc.creatorJosé-Manuel Aguirre-Urizarpt_BR
dc.creatorOslei-Paes de Almeidapt_BR
dc.date.accessioned2023-11-14T20:32:50Z-
dc.date.available2023-11-14T20:32:50Z-
dc.date.issued2019-04-24-
dc.citation.issue3pt_BR
dc.citation.spagee290pt_BR
dc.citation.epagee295pt_BR
dc.identifier.doihttps://doi.org/10.4317%2Fmedoral.22817pt_BR
dc.identifier.issn16986946pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/60972-
dc.description.resumoBackground The presence of human papilloma virus in benign oral lesions has been studied by different techniques obtaining extremely variable results. The objective of this study was to determine the presence of human papillomavirus in 83 cases of benign hyperplastic epithelial oral lesions. Material and Methods Eighty-three oral lesions with clinical or histopathological features suggestive of HPV infection were retrieved from the files of four oral pathology services. Demographic data were obtained from patient´s medical charts. All cases had available clinical image, H&E preparations and paraffin blocks with enough tissue for HPV detection by in situ hybridization, and immunohistochemical reactions for Ki67. Results Episomal positivity for wide spectrum HPV was observed in 24% of the cases; most of them (70%) HPV 6/11 positive. HPV 16/18 was not detected. Condyloma acuminatum was the most common lesion associated with HPV (75%), followed by verruca vulgaris (15%), squamous papilloma and multifocal epithelial hyperplasia, 5% each. Koilocytes were identified in all the HPV positive cases. Ki67 showed an abnormal proliferation pattern in 90% of the HPV positive cases; most of them (70%) showing groups of proliferating cells in focal superficial regions, and in 20% positivity was seen almost in the whole thickness of the epithelium. HPV negative cases showed Ki67 positive cells restricted to the basal layer. Conclusions Regarding oral lesions associated with HPV, condyloma is the most common lesion expressing low-risk subtypes. The etiology of squamous papilloma remains controversial as HPV was found in 1.9% of the cases. The identification of koilocytes and the pattern of expression of Ki67 reflect HPV infection and are helpful for classification. Papillary oral lesions not associated to HPV deserve further studies to better clarify its etiology.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofMedicina Oral Patologia Oral y Cirugia Bucalpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectspt_BR
dc.subjectBenign epithelial oral lesions - association with human Papillomavirus busca dia 03 do 10 ano 2023 fao clinica open acess assunto Human Papillomavirus Virusespt_BR
dc.subject.otherHuman Papillomavirus virusespt_BR
dc.subject.otherPapillomapt_BR
dc.subject.otherHyperplasiapt_BR
dc.subject.otherKi-67 antigenpt_BR
dc.titleBenign epithelial oral lesions - association with human Papillomaviruspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530955/pt_BR
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