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Tipo:	Artigo de Periódico
Título:	Benign epithelial oral lesions - association with human Papillomavirus
Autor(es):	Alicia-Rumayor Piña Felipe Paiva Fonseca Flávia-Sirotheau-Corrêa Pontes Hélder Antônio Rebelo Pontes Fábio-Ramôa Pires Adalberto-Mosqueda Taylor José-Manuel Aguirre-Urizar Oslei-Paes de Almeida
Resumo:	Background The presence of human papilloma virus in benign oral lesions has been studied by different techniques obtaining extremely variable results. The objective of this study was to determine the presence of human papillomavirus in 83 cases of benign hyperplastic epithelial oral lesions. Material and Methods Eighty-three oral lesions with clinical or histopathological features suggestive of HPV infection were retrieved from the files of four oral pathology services. Demographic data were obtained from patient´s medical charts. All cases had available clinical image, H&E preparations and paraffin blocks with enough tissue for HPV detection by in situ hybridization, and immunohistochemical reactions for Ki67. Results Episomal positivity for wide spectrum HPV was observed in 24% of the cases; most of them (70%) HPV 6/11 positive. HPV 16/18 was not detected. Condyloma acuminatum was the most common lesion associated with HPV (75%), followed by verruca vulgaris (15%), squamous papilloma and multifocal epithelial hyperplasia, 5% each. Koilocytes were identified in all the HPV positive cases. Ki67 showed an abnormal proliferation pattern in 90% of the HPV positive cases; most of them (70%) showing groups of proliferating cells in focal superficial regions, and in 20% positivity was seen almost in the whole thickness of the epithelium. HPV negative cases showed Ki67 positive cells restricted to the basal layer. Conclusions Regarding oral lesions associated with HPV, condyloma is the most common lesion expressing low-risk subtypes. The etiology of squamous papilloma remains controversial as HPV was found in 1.9% of the cases. The identification of koilocytes and the pattern of expression of Ki67 reflect HPV infection and are helpful for classification. Papillary oral lesions not associated to HPV deserve further studies to better clarify its etiology.
Assunto:	Human Papillomavirus viruses Papilloma Hyperplasia Ki-67 antigen
Idioma:	eng
País:	Brasil
Editor:	Universidade Federal de Minas Gerais
Sigla da Instituição:	UFMG
Departamento:	FAO - DEPARTAMENTO DE CLÍNICA
Tipo de Acesso:	Acesso Aberto
Identificador DOI:	https://doi.org/10.4317%2Fmedoral.22817
URI:	http://hdl.handle.net/1843/60972
Data do documento:	24-Abr-2019
metadata.dc.url.externa:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530955/
metadata.dc.relation.ispartof:	Medicina Oral Patologia Oral y Cirugia Bucal
Aparece nas coleções:	Artigo de Periódico

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