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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61014
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dc.creatorGleyson Kleber do Amaral Silvapt_BR
dc.creatorVivian Petersen Wagnerpt_BR
dc.creatorLaryssa Moura Diaspt_BR
dc.creatorBruno Augusto Linhares Almeida Marizpt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorAna Lúcia Carrinho Ayroza Rangelpt_BR
dc.creatorVirgilio Gonzales Zanellapt_BR
dc.creatorRogério Moraes Castilhopt_BR
dc.creatorManoela Domingues Martinspt_BR
dc.creatorPablo Agustin Vargaspt_BR
dc.date.accessioned2023-11-16T21:18:37Z-
dc.date.available2023-11-16T21:18:37Z-
dc.date.issued2022-02-20-
dc.citation.volume27pt_BR
dc.citation.issue2pt_BR
dc.citation.spagee164pt_BR
dc.citation.epagee173pt_BR
dc.identifier.doihttps://doi.org/10.4317%2Fmedoral.25138pt_BR
dc.identifier.issn1698-6946pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61014-
dc.description.resumoBackground Appropriate DNA replication is vital to maintain cell integrity at the genomic level. Malfunction on DNA repair mechanisms can have implications related to tumor behavior. Our aim was to evaluate the expression of key complexes of the DNA mismatch-repair system MutSα (hMSH2-hMSH6) and MutSβ (hMSH2-hMSH3) in a panel comprising the most common benign and malignant salivary gland tumors (SGT), and to determine their association with disease-free survival. Material and Methods Ten cases of normal salivary gland (NSG) and 92 of SGT (54 benign and 38 malignant) were retrieved. Immunohistochemistry was performed for hMSH2, hMSH3, hMSH6. Scanned slides were digitally analyzed based on the percentage of positive cells with nuclear staining. Cases were further classified in MutSαhigh and MutSβhigh based on hMSH2-hMSH6 and hMSH3-hMSH6 expression, respectively. Results hMSH3 expression was lower in malignant SGT compared to NSG and benign cases. Adenoid cystic carcinoma (ACC) cases with perineural invasion presented a lower percentage of hMSH3 positive cells. hMSH6 was downregulated in both benign and malignant SGT compared to NSG. Malignant SGT cases with MutSαhigh expression had lower disease-free survival compared to MutSαlow cases. A 10.26-fold increased risk of presenting local recurrence was observed. Conclusions Our findings suggest that a lack of hMSH3 protein function is associated with a more aggressive phenotype (malignancy and perineural invasion) and that MutSα overexpression predicts a poor clinical outcome in malignant SGT.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofMed Oral Patol Oral Cir Bucalpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectSalivary Gland Neoplasmspt_BR
dc.subjectSalivary gland cancerpt_BR
dc.subjectDNA-repairpt_BR
dc.subjectBiomarkerspt_BR
dc.subjectPrognosispt_BR
dc.subject.otherTumorespt_BR
dc.subject.otherBiomarcadorespt_BR
dc.subject.otherGlândulas Salivarespt_BR
dc.subject.otherReparo do DNApt_BR
dc.subject.otherNeoplasiaspt_BR
dc.titleMutSα expression predicts a lower disease-free survival in malignant salivary gland tumors: an immunohistochemical studypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898574/pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6657-4547pt_BR
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