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Type:	Artigo de Periódico
Title:	Immunology and immunopathogenesis of human leishmaniasis
Authors:	Juliana P. B. de Menezes Cláudia Brodskyn Ricardo Gonçalves Olivia Bacellar
Abstract:	Leishmaniasis is a disease that affects people and animals worldwide and can be broadly divided into visceral (VL) and tegumentary (TL) forms. TL caused by Leishmania braziliensis presents a wide spectrum de clinical manifestations ranging from a single and typical ulcer known as CL to the involvement of nasal or oral mucosal, mucosal leishmaniasis (ML). Between both clinical forms, there is diffuse cutaneous leishmaniasis (DCL) caused by Leishmania amazonensis. This spectrum included atypical cutaneous leishmaniasis (ACL) characterized by vegetative, verrucous, crusted and lupoid lesions (Guimarães et al., 2016). Human VL is characterized by depressed cell-mediated immunity and decreased Th1 immune response (Carvalho et al., 1989; Bacellar et al., 2000). Also, VL is associated with increased production of multiple pro-inflammatory cytokines and chemokines (Saporito et al., 2013; Palacios et al., 2021; Tasew et al., 2021).
Subject:	Leishmania Pioglitazona Patogênese Homeopática
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICB - DEPARTAMENTO DE PATOLOGIA ICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.3389/fcimb.2022.1055221
URI:	http://hdl.handle.net/1843/61292
Issue Date:	2022
metadata.dc.url.externa:	https://www.frontiersin.org/articles/10.3389/fcimb.2022.1055221/full
metadata.dc.relation.ispartof:	Frontiers in Cellular and Infection Microbiology
Appears in Collections:	Artigo de Periódico

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