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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61315
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dc.creatorCarla Isabelly Rodrigues- Fernandespt_BR
dc.creatorPablo Agustin Vargaspt_BR
dc.creatorLucas Guimarães Abreupt_BR
dc.creatorRaghu Radhakrishnanpt_BR
dc.creatorDanyel Elias da Cruz Perezpt_BR
dc.creatorGleyson Kleber Amaral- Silvapt_BR
dc.creatorRogério de Oliveira Gondakpt_BR
dc.creatorSiavash Rahimipt_BR
dc.creatorPeter Brennanpt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.date.accessioned2023-11-23T18:46:00Z-
dc.date.available2023-11-23T18:46:00Z-
dc.date.issued2021-
dc.citation.volume50pt_BR
dc.citation.issue6pt_BR
dc.citation.spage587pt_BR
dc.citation.epage593pt_BR
dc.identifier.doihttps://doi.org/10.1111/jop.13208pt_BR
dc.identifier.issn09042512pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61315-
dc.description.resumoBackground: CD30 is variably expressed in diffuse large B-cell lymphoma (DLBCL), but its prognostic potential for the affected patients remains debatable and unclear. Therefore, we aimed to determine the frequency of CD30 expression in DLBCL and its potential for prognostic determination. Methods: An electronic systematic review was performed using multiple databases, followed by a quantitative meta-analysis to assess the frequency of CD30 expression with positivity cut-off values of >0% and >20%, and to determine its association with clinicopathological features and patients' survival. Results: Using a cut-off value >0%, we observed that 3.5%-59.1% of the cases were considered positive for CD30. There was a significant association of the protein expression with a lower number of extra-nodal sites affected by the neoplasm, with Ann Arbor advanced stage, the absence of B-symptoms, the lack of MYC and BCL2 translocations, and a lower ECOG performance. Using a cut-off value >20%, we observed that 2.5%-36.7% of the cases were considered positive for CD30, being significantly associated with a lower number of extra-nodal sites affected by the neoplasm, Ann Arbor stages III/IV, non-GCB tumours, the lack of MYC and BCL2 translocations, and a lower ECOG value. CD30 expression was significantly associated with a better survival rate, regardless of what cut-off parameter was used. Conclusion: Despite variations in the cut-off values used to determine CD30 positivity in DLBCL, the expression of this protein seems to be associated with a higher survival rate and better prognosis.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Oral Pathology & Medicinept_BR
dc.rightsAcesso Restritopt_BR
dc.subjectLinfomapt_BR
dc.subjectnome periódico Journal of oral pathology & medicineacesso restrito nome periódico Journal of oral pathology & medicine Prognostic significance of cd30 expression in diffuse large b-cell lymphoma: a systematic review with meta-analysis fao clinica e fao odontopediatria assunto Brentuximab Vedotin busca dia 07 do 11 novembro ano 2023pt_BR
dc.subject.otherBrentuximab vedotinpt_BR
dc.subject.otherKi-1 Antigenpt_BR
dc.subject.otherLymphoma, B-Cellpt_BR
dc.subject.otherLymphomapt_BR
dc.subject.otherPrognosispt_BR
dc.subject.otherSurvival ratept_BR
dc.subject.otherProteinspt_BR
dc.subject.otherSystematic reviewpt_BR
dc.titlePrognostic significance of CD30 expression in diffuse large b-cell lymphoma: a systematic review with meta-analysispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.13208pt_BR
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