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http://hdl.handle.net/1843/61322
Type: | Artigo de Periódico |
Title: | The prognostic significance of immunophenotypes in canine malignant mammary tumors |
Other Titles: | Significância prognóstica dos imunofenótipos em tumores mamários malignos caninos |
Authors: | F.C. Nunes A.C. Bertagnolli Gleidice Eunice Lavalle T.L. Silveira Debora Balabram Geovanni Dantas Cassali |
Abstract: | Canine malignant mammary neoplasms (CMMN) exhibit behavioral variability with the patient survival time depending on several prognostic factors. In the present study, 134 CMMN were selected and different immunophenotypes and their associations with clinical and pathological parameters were identified. The tumors were classified as follows: 46% of luminal B HER2-, 34% of luminal A, 13% of triple-negative, and 7% of luminal B HER2+. Shorter specific survival time were associated with larger tumor sizes (>3.0 cm, HR=1.94; P=0.0209), lymph node metastasis or distant metastasis (HR= 2.82; P <.0001), more aggressive histological types (HR= 7.15, P<0.0001), higher histological grades (HR= 12.97 P=0.011), angiolymphatic invasion (HR=4.68, P<0.0001) and luminal B HER2 - (HR= 3.27, P<0.0001) and luminal B HER2 + (HR= 7.14 P<0.0001) immunophenotypes. In patients with lymph nodal metastasis, shorter survival times were associated with luminal immunophenotype B HER2 + (P=0.003). However, in patients without metastasis, an increased risk of death was associated with the aggressive histological type. In conclusion, the classification in our study allowed us to identify subtypes with different prognoses in canine malignant mammary tumors. Factors such as clinical stage, histological type, luminal B HER2+ subtype, and angiolymphatic invasion were the most important prognostic factors. |
Abstract: | Neoplasias mamárias malignas caninas (CMMN) apresentam variável comportamento biológico e o tempo de sobrevida depende de diversos fatores prognósticos. Neste estudo, foram selecionadas 134 CMMN, bem como identificados diferentes imunofenótipos e suas associações com parâmetros clínicos e patológicos. Os tumores foram classificados em: 46% luminal B HER2-, 34% luminal A, 13% triplo negativo e 7% luminal B HER2+. Menores taxas de sobrevida específica foram associadas a tamanhos de tumor maiores (> 3,0cm; HR = 1,94; P = 0,0209), metástases em nodais ou a distância (HR = 2,82; P <0,0001), tipos histológicos mais agressivos (HR = 7,15; P <0,0001), graus histológicos mais elevados (HR = 12,97; P = 0,011), invasão angiolinfática (HR = 4,68; P <0,0001) e aos imunofenótipos luminal B HER2- (HR = 3,27; P <0,0001) e luminal B HER2+ ( HR = 7,14; P <0,0001). Em pacientes com estágio avançado, menor sobrevida específica foi associada ao imunofenótipo luminal B HER2+ (P = 0,003). Entretanto, em estágio inicial, um risco aumentado de óbito foi associado a tipos histológicos agressivos. Em conclusão, a classificação utilizada no presente estudo permitiu identificar subtipos com diferentes prognósticos em CMMN. Estágio clínico, tipo histológico, subtipo luminal B HER2+ e invasão angiolinfática foram os fatores prognósticos mais importantes. |
Subject: | Carcinoma Glândulas mamárias Fenobarbital Tumores |
language: | eng |
metadata.dc.publisher.country: | Brasil |
Publisher: | Universidade Federal de Minas Gerais |
Publisher Initials: | UFMG |
metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE PATOLOGIA ICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS MED - DEPARTAMENTO DE CIRURGIA |
Rights: | Acesso Aberto |
metadata.dc.identifier.doi: | https://doi.org/10.1590/1678-4162-12273 |
URI: | http://hdl.handle.net/1843/61322 |
Issue Date: | 2022 |
metadata.dc.url.externa: | https://www.scielo.br/j/abmvz/a/fd8NJtQTLtXpVng4wJHd7TQ/?lang=en |
metadata.dc.relation.ispartof: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia |
Appears in Collections: | Artigo de Periódico |
Files in This Item:
File | Description | Size | Format | |
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The prognostic significance of immunophenotypes in canine malignant mammary tumors.pdf | 432.59 kB | Adobe PDF | View/Open |
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