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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61359
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dc.creatorPatricia Verónica Aulestia Vierapt_BR
dc.creatorSávio Morato Lacerda Gontijopt_BR
dc.creatorAlinne Damásia Martins Gomespt_BR
dc.creatorRubén Dario Sinisterra Millánpt_BR
dc.creatorRodney Garcia Rochapt_BR
dc.creatorMaría Esperanza Cortés Segurapt_BR
dc.creatorMarinilce Fagundes dos Santospt_BR
dc.creatorMaria Aparecida Borsattipt_BR
dc.date.accessioned2023-11-24T19:30:32Z-
dc.date.available2023-11-24T19:30:32Z-
dc.date.issued2019-
dc.citation.volume23pt_BR
dc.citation.issue1pt_BR
dc.citation.spage53pt_BR
dc.citation.epage61pt_BR
dc.identifier.doihttps://doi.org/10.1007/s10006-019-00747-4pt_BR
dc.identifier.issn1865-1569pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61359-
dc.description.resumoPurpose: Dry socket (DS) is one the most common and symptomatic post-extraction complications; however, no consensus on its treatment has been reached. This study aimed to develop a novel dressing material for DS containing the phenolic agent guaiacol and evaluate its biological properties. Methods: An inclusion complex of guaiacol and β-cyclodextrin (Gu/βcd) was prepared by freeze-drying. Its antibacterial activity over six oral bacteria was analyzed using the microdilution method, and its cytotoxicity in osteoblasts was assessed with the MTT assay. The alveolar healing process induced by Gu/βcd was evaluated histologically after the treatment of DS in rats. Results: βcd complexation potentiated Gu’s antibacterial effect and reduced its cytotoxicity in osteoblasts. Bone trabeculae were formed in the alveolar apices of rats treated with Gu/βcd by day 7. On day 14, woven bone occupied the apical and middle thirds of the sockets; on day 21, the entire alveolus was filled by newly formed bone, which was in a more advanced stage of repair than the positive control (Alvogyl™). Conclusion: The improvement in Gu’s biological properties in vitro and the rapid alveolar repair in comparison with Alvogyl™ in vivo demonstrated the benefits of the Gu/βcd complex as a future alternative for the treatment of DS.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofOral and Maxillofacial Surgerypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectAntibacterial agentpt_BR
dc.subjectCytotoxicitypt_BR
dc.subjectDry socketpt_BR
dc.subjectGuaiacolpt_BR
dc.subjectOral surgerypt_BR
dc.subjectAnimal studypt_BR
dc.subject.otherCiclodextrinaspt_BR
dc.subject.otherCicatrização de feridaspt_BR
dc.subject.otherAgentes antibacterianospt_BR
dc.subject.otherBoca - Cirurgiapt_BR
dc.subject.otherOssos - Regeneraçãopt_BR
dc.subject.otherAlveolitept_BR
dc.subject.otherSecagem por congelaçãopt_BR
dc.titleGuaiacol/β-cyclodextrin for rapid healing of dry socket: antibacterial activity, cytotoxicity, and bone repair-an animal studypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s10006-019-00747-4pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3860-2360pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7803-4345pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7656-1849pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0560-8491pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3257-3327pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1413-0004pt_BR
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