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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61395
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dc.creatorRicardo Ramírez-Agudelopt_BR
dc.creatorKarina Scheuermannpt_BR
dc.creatorAlfonso Gala Garcíapt_BR
dc.creatorAna Paula de Figueiredo Monteiropt_BR
dc.creatorAna Delia Pinzón Garcíapt_BR
dc.creatorMaría Esperanza Cortés Segurapt_BR
dc.creatorRubén Dario Sinisterra Millánpt_BR
dc.date.accessioned2023-11-27T18:42:02Z-
dc.date.available2023-11-27T18:42:02Z-
dc.date.issued2018-02-
dc.citation.volume83pt_BR
dc.citation.spage25pt_BR
dc.citation.epage34pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.msec.2017.08.012pt_BR
dc.identifier.issn0928-4931pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61395-
dc.description.resumoCancer is one of the leading causes of morbidity and mortality Worldwide, 19.3 million new cancer cases are expected to be identified in 2025. Among the therapeutic arsenal to cancer control one could find the Doxycycline and the nano hydroxyapatite. The Doxycycline (Dox) not only shown antibiotic effect but also exhibits a wide range of pleiotropic therapeutic properties as the control of the invasive and metastatic cancer cells characteristics. The purpose of the present study was to evaluate both cytotoxicity in vitro and antibacterial activity of electrospun Dox-loaded hybrid nanofibrous scaffolds composed by hydroxyapatite nanoparticles (nHA), poly-ε-caprolactone (PCL) and gelatin (Gel) polymers. Both nHA and Dox were dispersed into different PCL/Gel ratios (70:30, 60:40, 50:50 wt%) solutions to form electrospun nanofibers. The nHA and Dox/nHA/PCL-Gel hybrid nanofibers were characterized by TEM microscopy. In vitro Dox release behavior from all of these Dox-loaded nHA/PCL-Gel nanofibers showed the same burst release profile due to the high solubility of Gel in the release medium. Antibacterial properties of nanofiber composites were evaluated using Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Porphyromonas gingivalis (P. gingivalis) bacteria. The co-delivery of nHA particles and Dox simultaneously exhibited inhibition of bacterial growth more efficiently than the delivery of either Dox or nHA at the same concentrations, indicating a synergistic effect. The results showed that cancer cell tested had different sensibility to co-delivery system. On the whole, A-431 cells were found exhibited the most pronounced synergistic effect compared to CACO-2 and 4T1 cancer cells. Based on the anticancer as well as the antimicrobial results in this study, the developed Dox/nHA/PCL-Gel composite nanofibers are suitable as a drug delivery system with potential applications in the biomedical fields.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofMaterials Science and Engineering: Cpt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectPCL/Gel nanofiberspt_BR
dc.subjectDrug deliverypt_BR
dc.subjectHydroxyapatite nanoparticlespt_BR
dc.subjectDoxycyclinept_BR
dc.subjectCombination chemotherapypt_BR
dc.subjectAntibacterial activitypt_BR
dc.subject.otherSistema de distribuição de medicamentospt_BR
dc.subject.otherQuimioterapia combinadapt_BR
dc.subject.otherAgentes antibacterianospt_BR
dc.subject.otherAgentes antineoplásicospt_BR
dc.subject.otherNanopartículaspt_BR
dc.subject.otherHidroxiapatitapt_BR
dc.subject.otherTetraciclinapt_BR
dc.titleHybrid nanofibers based on poly-caprolactone/gelatin/hydroxyapatite nanoparticles-loaded Doxycycline: effective anti-tumoral and antibacterial activitypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0928493117321513pt_BR
dc.identifier.orcidhttps://orcid.org/0009-0001-5010-7450pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8216-1788pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3934-1094pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4202-1964pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8876-4907pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0560-8491pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7656-1849pt_BR
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