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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61410
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dc.creatorGustavo Cancela e Pennapt_BR
dc.creatorRachel Cardoso Lopes Regopt_BR
dc.creatorGabriela Malta Silva Dinizpt_BR
dc.creatorGabriela Maciel Campolina Cardosopt_BR
dc.creatorRudolf Moreira Pfeilstickerpt_BR
dc.creatorAdelina Sanchespt_BR
dc.creatorBarbara Moreira Ribeiro Trindade dos Santospt_BR
dc.creatorHans Grafpt_BR
dc.date.accessioned2023-11-27T19:37:19Z-
dc.date.available2023-11-27T19:37:19Z-
dc.date.issued2022-
dc.citation.volume3pt_BR
dc.citation.issue3pt_BR
dc.citation.spage240pt_BR
dc.citation.epage245pt_BR
dc.identifier.doihttp://dx.doi.org/10.37871/jbres1429pt_BR
dc.identifier.issn2766-2276pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61410-
dc.description.resumoIntroduction: Thyroidectomy is the treatment of choice for non-toxic compressive Multinodular Goiter (MNG). However, when surgery is contraindicated, other therapeutic options should be evaluated. In this case report, non-surgical therapeutic possibilities are reviewed, and the results obtained with Radioiodine Therapy (RAI) after stimulating with Recombinant Thyroid-Stimulating Hormone (rhTSH) are described. Case report: A 92-year-old patient with multiple comorbidities, non-toxic MNG, and symptomatic compression of the trachea and esophagus. Accordingly, RAI was chosen due to the high surgical risk. Initially, pre-treatment with methimazole was performed to increase TSH, which was interrupted due to drug hepatitis. Then, RAI was chosen in the post-stimulus with a low dose of rhTSH, with significant and early reduction of goiter and symptoms. Discussion: Although total thyroidectomy is the treatment of choice for non-toxic and symptomatic intrathoracic MNG; it does present risks, especially in patients with multiple comorbidities. Thus, interest in less invasive techniques is increasing. Thermal radio-ablations exhibit satisfactory results, however it is still an inaccessible technique. Radioiodine is an effective treatment option subsequent to the use of rhTSH or hypothyroidism methimazole-induced. RhTSH and methimazole can increase the level of radiation absorbed by the gland, which can lead to a reduction in the required I-131 dose. Conclusion: It is possible to mitigate the symptoms and improve the quality of life of patients with non-toxic and symptomatic MNG and multiple comorbidities, without surgical intervention. In this case report we describe alternatives to surgical intervention and show the effectiveness and safety of RAI along with rhTSH in the management of MNG.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Biomedical Research and Environmental Sciencespt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectGoiterpt_BR
dc.subjectThyroid nodulept_BR
dc.subject.otherBóciopt_BR
dc.subject.otherNódulo da glândula tireoidept_BR
dc.subject.otherTireoidectomiapt_BR
dc.titleCompressive non-toxic intrathoracic goiter in patient with contraindication to surgical treatment: case reportpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.jelsciences.com/articles/jbres1429.phppt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2125-7051pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4832-3955pt_BR
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