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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61417
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dc.creatorVinícius Souza Tarabalpt_BR
dc.creatorFlávia Gontijo da Silvapt_BR
dc.creatorRubén Dario Sinisterra Millánpt_BR
dc.creatorDaniel Bonoto Gonçalvespt_BR
dc.creatorJosé Antonio Silvapt_BR
dc.creatorJose Mauro Granjeiropt_BR
dc.creatorMarcelo Gomes Spezialipt_BR
dc.creatorPaulo Afonso Granjeiropt_BR
dc.date.accessioned2023-11-27T19:58:09Z-
dc.date.available2023-11-27T19:58:09Z-
dc.date.issued2021-
dc.citation.volume15pt_BR
dc.citation.issue1pt_BR
dc.citation.spage54pt_BR
dc.citation.epage66pt_BR
dc.identifier.doihttp://dx.doi.org/10.2174/1872208315666210215084127pt_BR
dc.identifier.issn2212-4012pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61417-
dc.description.resumoBackground: Microorganisms can migrate from the external environment to the patient’s organism through the insertion of catheters. Despite being indispensable medical device, the catheter surface can be colonized by microorganisms and become a starting point for biofilm formation. Therefore, new technologies are being developed in order to modify surfaces to prevent the adhesion and survival of microorganisms. Patents with the use of DMPEI have been filed. Objective: In the present work, we coated latex catheter surfaces with 2 mg mL-1 DMPEI in different solvents, evaluated the wettability of the surface and the anti- biofilm activity of the coated catheter against Escherichia coli, Staphylococcus aureus, and Candida albicans. Methods: We coated the inner and outer catheter surfaces with 2 mg mL-1 of DMPEI solubilized in butanol, dimethylformamide, and cyclohexanone and the surfaces were analyzed visually. Contact angle measurement allowed the analysis of the wettability of the surfaces. The CFU mL-1 count evaluated E. coli, S. aureus, and C. albicans adhesion onto the control and treated surfaces. Results: The contact angle decreased from 50.48º to 46.93º on the inner surface and from 55.83º to 50.91º on the outer surface of latex catheters coated with DMPEI. The catheter coated with DMPEI showed anti-biofilm activity of 83%, 88%, and 93% on the inner surface and 100%, 92%, and 86% on the outer surface for E. coli, S. aureus, and C. albicans, respectively. Conclusion: Latex catheter coated with DMPEI efficiently impaired the biofilm formation both on the outer and inner surfaces, showing a potential antimicrobial activity along with a high anti-biofilm activity for medical devices.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofRecent Patents on Biotechnologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectCatheter-associated urinary tract infectionpt_BR
dc.subjectDMPEIpt_BR
dc.subjectBiofilmpt_BR
dc.subjectUrinary catheterpt_BR
dc.subjectLatexpt_BR
dc.subject.otherBiofilmept_BR
dc.subject.otherCateterespt_BR
dc.subject.otherLatexpt_BR
dc.subject.otherBiotecnologia microbianapt_BR
dc.subject.otherInfecções urináriaspt_BR
dc.subject.otherAgentes antiinfecciosospt_BR
dc.titleImpact of DMPEI on biofilm adhesion on latex urinary catheterpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.eurekaselect.com/article/114184pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8736-8531pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7284-2026pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7656-1849pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8178-1026pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8027-8293pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3572-9670pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0322-0861pt_BR
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