Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/61420| Type: | Artigo de Periódico |
| Title: | Role of yes-associated protein and transcriptional coactivator with PDZ-binding motif in the malignant transformation of oral submucous fibrosis |
| Authors: | Mohit Sharma Keith Hunter Felipe Paiva Fonseca Smitha Sammith Shetty Raghu Radhakrishnan |
| Abstract: | Objective(s): The objective of the present manuscript is to elucidate the role of matrix stiffness in the malignant transformation of oral submucous fibrosis. Design: The role of matrix stiffness in several cancers including oral cancer was reviewed with a tailored search strategy using relevant keywords as per the Medline format. The role of molecular mediators, Yes-associated protein 1 (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) was weighed in the context of OSF along two distinct pathways. Results: Increased matrix stiffness activates the transcriptional coactivators, YAP and TAZ shuttling between the nucleus and cytoplasm. YAP and TAZ, serve as mechanical transducers in promoting cell migration, invasion and epithelial-mesenchymal transition (EMT). The hypoxic microenvironment in the advanced stage of OSF promotes the migratory phenotype through mechanical memory. Conclusions: Reprogramming of a stiff matrix has the potential to restore the Hippo-YAP/TAZ tumor suppressor pathway and reverse fibrosis-associated tumor development. |
| Subject: | Cellular senescence Hippo signaling pathway Mouth neoplasms Oral submucous fibrosis Proteins |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.archoralbio.2021.105164 |
| URI: | http://hdl.handle.net/1843/61420 |
| Issue Date: | Aug-2021 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0003996921001278?via%3Dihub |
| metadata.dc.relation.ispartof: | Archives of Oral Biology |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.