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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61529
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dc.creatorAnna Luíza Araújopt_BR
dc.creatorOslei de Almeidapt_BR
dc.creatorJéssica Fonsêcapt_BR
dc.creatorGleyson Kleber do Amaral-Silvapt_BR
dc.creatorThayná de Lima Moraispt_BR
dc.creatorBruno Marizpt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorMarcio Lopespt_BR
dc.creatorPablo Vargaspt_BR
dc.creatorAlan Santos-Silvapt_BR
dc.date.accessioned2023-11-29T20:02:23Z-
dc.date.available2023-11-29T20:02:23Z-
dc.date.issued2021-
dc.citation.volume29pt_BR
dc.citation.spage781pt_BR
dc.citation.epage790pt_BR
dc.identifier.doi10.1097/PAI.0000000000000960pt_BR
dc.identifier.issn15412016pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61529-
dc.description.resumoA proper antibody panel selection is one of the most important factors to reach an adequate diagnosis in challenging cases. This retrospective study was designed to determine the contribution of immunohistochemistry (IHC) in the primary diagnosis of oral diseases in one of the main services of oral pathology in the State of São Paulo, Brazil, and to identify the most common antibodies used, and recommend diagnostic algorithms based on our experience with challenging lesions. A total of 1698 IHC stains were performed in 401 cases from a total of 28,804 cases received from public dental clinics and private dental practitioners within a period of 13 years, representing a frequency of 1.4% of IHC solicitations. Among these, 112 (28%) were mandatory to reach a final diagnosis and 255 (63.6%) were confirmative. In 34 (8.4%) cases, it was not possible to reach a conclusive/final diagnosis, even with IHC. Regarding the nature of the lesions, 210 (52.3%) were benign, 163 (40.6%) were malignant tumors, 13 (3.2%) were reactive, 10 (2.5%) were premalignant, and 5 (1.2%) were lesions of uncertain malignancy. Small amount of tissue of some incisional biopsies, overlapping features of spindle cell lesions (epithelial, neural, melanocytic, smooth muscle, endothelial, and fibroblastic/myofibroblastic cell differentiation), and overlapping features of salivary gland lesions were the most frequent challenges in which IHC stains were requested. Spindle cell lesions were the most frequent (22%) among all cases that required IHC to reach a final diagnosis. The implementation of IHC for routine practice requires a wide range of markers, proper antibody selection, and knowledge to interpret the subjectivity of staining. The inherent limitation of incisional biopsies was pointed as a reason to inconclusive diagnosis, despite a wide range of antibodies that our laboratory displays.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofApplied Immunohistochemistry & Molecular Morphologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectPatologia oralpt_BR
dc.subjectacesso restrito buy comprar em inglês busca dia 08 do 11 ano 2023The role of immunohistochemistry for primary oral diagnosis in a brazilian oral pathology service nome periódico Applied immunohistochemistry & molecular morphology fao clínica assunto Immunohistochemistrypt_BR
dc.subject.otherImmunohistochemistrypt_BR
dc.subject.otherDiagnosispt_BR
dc.subject.otherAntibodiespt_BR
dc.subject.otherPathology, oralpt_BR
dc.subject.otherBiopsypt_BR
dc.subject.otherMouth neoplasmspt_BR
dc.titleThe role of immunohistochemistry for primary oral diagnosis in a brazilian oral pathology servicept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.lww.com/appliedimmunohist/fulltext/2021/11000/the_role_of_immunohistochemistry_for_primary_oral.10.aspxpt_BR
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