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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61592
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dc.creatorLucas Lacerda de Souzapt_BR
dc.creatorRicardo Alves Mesquitapt_BR
dc.creatorFlávia Sirotheau Correa Pontespt_BR
dc.creatorWilfredo Alejandro González-Arriagadapt_BR
dc.creatorRicardo Martinez Pedrazapt_BR
dc.creatorBruno Augusto Benevenuto de Andradept_BR
dc.creatorMario José Romañachpt_BR
dc.creatorCiro Dantas Soarespt_BR
dc.creatorMaria Goretti Freire de Carvalhopt_BR
dc.creatorFabio Ramôa Pirespt_BR
dc.creatorRoman Carlospt_BR
dc.creatorCinthia Veronica Bardalez Lopez de Cacerespt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorHélder Antônio Rebelo Pontespt_BR
dc.creatorOslei Paes Almeidapt_BR
dc.creatorPablo Agustin Vargaspt_BR
dc.creatorMárcio Ajudarte Lopespt_BR
dc.creatorAlan Roger Santos-Silvapt_BR
dc.creatorWagner Gomes da Silvapt_BR
dc.creatorAna Carolina Prado-Ribeiropt_BR
dc.creatorThais Bianca Brandãopt_BR
dc.creatorJuliana Pereirapt_BR
dc.date.accessioned2023-11-30T20:08:56Z-
dc.date.available2023-11-30T20:08:56Z-
dc.date.issued2021-
dc.citation.volume50pt_BR
dc.citation.issue6pt_BR
dc.citation.spage613pt_BR
dc.citation.epage621pt_BR
dc.identifier.doihttps://doi.org/10.1111/jop.13213pt_BR
dc.identifier.issn16000714pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61592-
dc.description.resumoBackground: Plasma cell neoplasms are characterized by the proliferation of a single clone of plasma cells with production of a monoclonal immunoglobulin. They can manifest as a single lesion (plasmacytoma) or as multiple lesions (multiple myeloma). Methods: Paraffin-embedded tissue blocks of patients microscopically diagnosed with plasma cell neoplasms in the jaws were retrieved from five pathology files. Data including clinical, radiographic, microscopic and immunohistochemical findings, treatment employed and follow-up status were retrieved from the pathology reports. Results: Fifty-two cases were retrieved (mean age: 59.4 years) without sex predilection. The mandible was the most affected site (67.3%), usually associated with pain and/or paresthesia (53.8%). Lesions in other bones besides the jaws were reported for 24 patients (46.2%). Radiographically, tumours usually presented as poorly defined osteolytic lesions with unilocular or multilocular images, while microscopy revealed diffuse proliferation of neoplastic plasma cells with nuclear displacement and abundant eosinophilic cytoplasm. Two cases were classified as anaplastic, and amyloid deposits were found in two other cases. Immunohistochemistry was positive for plasma cell markers and negative for CD20 and CD3, and monoclonality for kappa light chain predominated. The overall survival rate after 5 years of follow-up was 26.6%. Conclusion: Plasma cell neoplasms are aggressive tumours with a poor prognosis and involvement of the jaws may be the first complaint of the patient. Thus, oral pathologists, head and neck surgeons and dentists should be aware of their clinical, radiographic and microscopic manifestations.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Oral Pathology & Medicinept_BR
dc.rightsAcesso Restritopt_BR
dc.subjectacesso restrito Plasmacytoma and plasma cell myeloma affecting the jaws: a multi-institutional collaborative study busca dia 13 do 11 2023 assunto mandible fao clínicapt_BR
dc.subjecttítulo periódico Journal of oral pathology & medicine (online) data publicação ano 2021pt_BR
dc.subject.otherMandiblept_BR
dc.subject.otherMultiple myelomapt_BR
dc.subject.otherMouthpt_BR
dc.subject.otherPlasmacytomapt_BR
dc.subject.otherNeoplasmspt_BR
dc.subject.otherPlasma cellspt_BR
dc.subject.otherImmunohistochemistrypt_BR
dc.titlePlasmacytoma and plasma cell myeloma affecting the jaws: a multi-institutional collaborative studypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.13213pt_BR
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