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http://hdl.handle.net/1843/61661
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DC Field | Value | Language |
---|---|---|
dc.creator | Carla Isabelly Rodrigues-Fernandes | pt_BR |
dc.creator | Débora Lima Pereira | pt_BR |
dc.creator | Luis Fernando Rivero | pt_BR |
dc.creator | Kelly Tambasco Bezerra | pt_BR |
dc.creator | Bruno Augusto Benevenuto de Andrade | pt_BR |
dc.creator | Mário José Romañach | pt_BR |
dc.creator | Michele Agostini | pt_BR |
dc.creator | Javier Rendón Henao | pt_BR |
dc.creator | Amanda de Farias Gabriel | pt_BR |
dc.creator | Décio dos Santos Pinto Júnior | pt_BR |
dc.creator | Manoela Domingues Martins | pt_BR |
dc.creator | Arnaldo Gonçalves Junior | pt_BR |
dc.creator | Mateus José de Carvalho Pereira | pt_BR |
dc.creator | Ricardo Alves Mesquita | pt_BR |
dc.creator | Ricardo Santiago Gomez | pt_BR |
dc.creator | Giovanna Ribeiro Souto | pt_BR |
dc.creator | Alan Roger Santos-Silva | pt_BR |
dc.creator | Pablo Agustin Vargas | pt_BR |
dc.creator | Márcio Ajudarte Lopes | pt_BR |
dc.creator | Oslei Paes de Almeida | pt_BR |
dc.creator | Flávia Sirotheau Corrêa Pontes | pt_BR |
dc.creator | Hélder Antônio Rebelo Pontes | pt_BR |
dc.creator | Ciro Dantas Soares | pt_BR |
dc.creator | Rommel Mario Rodríguez Burbano | pt_BR |
dc.creator | Felipe Paiva Fonseca | pt_BR |
dc.creator | Thayná Melo de Lima Morais | pt_BR |
dc.creator | Gleyson Kleber do Amaral-Silva | pt_BR |
dc.creator | Maria Goretti Freire de Carvalho | pt_BR |
dc.creator | Lucas Lacerda de Souza | pt_BR |
dc.creator | Fábio Ramôa Pires | pt_BR |
dc.creator | Teresa Cristina Ribeiro Bartholomeu dos Santos | pt_BR |
dc.date.accessioned | 2023-12-01T21:32:09Z | - |
dc.date.available | 2023-12-01T21:32:09Z | - |
dc.date.issued | 2021-04 | - |
dc.citation.volume | 131 | pt_BR |
dc.citation.issue | 4 | pt_BR |
dc.citation.spage | 452 | pt_BR |
dc.citation.epage | 462.e4 | pt_BR |
dc.identifier.doi | https://doi.org/10.1016/j.oooo.2020.11.005 | pt_BR |
dc.identifier.issn | 22124403 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/1843/61661 | - |
dc.description.resumo | Objective: The objective of this study was to describe the clinicopathological, molecular, and prognostic features of oral/oropharyngeal diffuse large B-cell lymphoma (DLBCL) and high-grade B-cell lymphoma. Study design: All cases were retrieved from 7 Brazilian institutions. Immunohistochemical reactions were performed to confirm the diagnoses and to categorize the tumors. In situ hybridization was used to detect Epstein-Barr virus (EBV) and fluorescence in situ hybridization was used to identify gene rearrangements. Results: Most cases involved the oral cavity (76.8%). Males and females, with a mean age of 60 years, were evenly affected. Tumors mostly presented as painful swellings. Forty cases represented germinal center B-cell type (58%). Five cases presented double-hit translocation and 3 harbored rearrangement for MYC/BCL2/BCL6. EBV was detected in 3 cases (4.3%). The 5-year overall survival was 44.4%. Female sex, presence of pain and ulcer, microscopic "starry sky pattern" and necrosis, co-expression of c-Myc/Bcl2, and translocation of MYC were associated with a lower survival in univariate analysis (P = .05, P = .01, P = .01, P = .03, P = .05, P = .006, P = .05, respectively). Conclusion: Patients affected by oral/oropharyngeal DLBCL have a low survival rate. High-grade B-cell lymphoma (17.7%) and EBV-positive DLBCL, not otherwise specified (4.3%) account for a small number of cases. | pt_BR |
dc.language | eng | pt_BR |
dc.publisher | Universidade Federal de Minas Gerais | pt_BR |
dc.publisher.country | Brasil | pt_BR |
dc.publisher.department | FAO - DEPARTAMENTO DE CLÍNICA | pt_BR |
dc.publisher.initials | UFMG | pt_BR |
dc.relation.ispartof | Oral Surgery Oral Medicine Oral Pathology Oral Radiology | pt_BR |
dc.rights | Acesso Restrito | pt_BR |
dc.subject | linfomas acesso restrito busca dia 23 do mês 11 novembro ano 2023 assunto Neoplasms fao clínica Oral and oropharyngeal diffuse large b-cell lymphoma and high-grade b-cell lymphoma: a clinicopathologic and prognostic study of 69 cases | pt_BR |
dc.subject | neoplasias de cabeça e pescoço título periódico: Oral surgery oral medicine oral pathology oral radiology | pt_BR |
dc.subject.other | Lymphoma, large B-Cell, diffuse | pt_BR |
dc.subject.other | Immunohistochemistry | pt_BR |
dc.subject.other | Neoplasms | pt_BR |
dc.subject.other | Survival rate | pt_BR |
dc.subject.other | Epstein-Barr virus infections | pt_BR |
dc.subject.other | Necrosis | pt_BR |
dc.subject.other | Prognosis | pt_BR |
dc.title | Oral and oropharyngeal diffuse large B-Cell lymphoma and high-grade B-Cell lymphoma: a clinicopathologic and prognostic study of 69 cases | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.url.externa | https://www.sciencedirect.com/science/article/pii/S2212440320313328?via%3Dihub | pt_BR |
Appears in Collections: | Artigo de Periódico |
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