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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61661
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dc.creatorCarla Isabelly Rodrigues-Fernandespt_BR
dc.creatorDébora Lima Pereirapt_BR
dc.creatorLuis Fernando Riveropt_BR
dc.creatorKelly Tambasco Bezerrapt_BR
dc.creatorBruno Augusto Benevenuto de Andradept_BR
dc.creatorMário José Romañachpt_BR
dc.creatorMichele Agostinipt_BR
dc.creatorJavier Rendón Henaopt_BR
dc.creatorAmanda de Farias Gabrielpt_BR
dc.creatorDécio dos Santos Pinto Júniorpt_BR
dc.creatorManoela Domingues Martinspt_BR
dc.creatorArnaldo Gonçalves Juniorpt_BR
dc.creatorMateus José de Carvalho Pereirapt_BR
dc.creatorRicardo Alves Mesquitapt_BR
dc.creatorRicardo Santiago Gomezpt_BR
dc.creatorGiovanna Ribeiro Soutopt_BR
dc.creatorAlan Roger Santos-Silvapt_BR
dc.creatorPablo Agustin Vargaspt_BR
dc.creatorMárcio Ajudarte Lopespt_BR
dc.creatorOslei Paes de Almeidapt_BR
dc.creatorFlávia Sirotheau Corrêa Pontespt_BR
dc.creatorHélder Antônio Rebelo Pontespt_BR
dc.creatorCiro Dantas Soarespt_BR
dc.creatorRommel Mario Rodríguez Burbanopt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorThayná Melo de Lima Moraispt_BR
dc.creatorGleyson Kleber do Amaral-Silvapt_BR
dc.creatorMaria Goretti Freire de Carvalhopt_BR
dc.creatorLucas Lacerda de Souzapt_BR
dc.creatorFábio Ramôa Pirespt_BR
dc.creatorTeresa Cristina Ribeiro Bartholomeu dos Santospt_BR
dc.date.accessioned2023-12-01T21:32:09Z-
dc.date.available2023-12-01T21:32:09Z-
dc.date.issued2021-04-
dc.citation.volume131pt_BR
dc.citation.issue4pt_BR
dc.citation.spage452pt_BR
dc.citation.epage462.e4pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2020.11.005pt_BR
dc.identifier.issn22124403pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61661-
dc.description.resumoObjective: The objective of this study was to describe the clinicopathological, molecular, and prognostic features of oral/oropharyngeal diffuse large B-cell lymphoma (DLBCL) and high-grade B-cell lymphoma. Study design: All cases were retrieved from 7 Brazilian institutions. Immunohistochemical reactions were performed to confirm the diagnoses and to categorize the tumors. In situ hybridization was used to detect Epstein-Barr virus (EBV) and fluorescence in situ hybridization was used to identify gene rearrangements. Results: Most cases involved the oral cavity (76.8%). Males and females, with a mean age of 60 years, were evenly affected. Tumors mostly presented as painful swellings. Forty cases represented germinal center B-cell type (58%). Five cases presented double-hit translocation and 3 harbored rearrangement for MYC/BCL2/BCL6. EBV was detected in 3 cases (4.3%). The 5-year overall survival was 44.4%. Female sex, presence of pain and ulcer, microscopic "starry sky pattern" and necrosis, co-expression of c-Myc/Bcl2, and translocation of MYC were associated with a lower survival in univariate analysis (P = .05, P = .01, P = .01, P = .03, P = .05, P = .006, P = .05, respectively). Conclusion: Patients affected by oral/oropharyngeal DLBCL have a low survival rate. High-grade B-cell lymphoma (17.7%) and EBV-positive DLBCL, not otherwise specified (4.3%) account for a small number of cases.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofOral Surgery Oral Medicine Oral Pathology Oral Radiologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectlinfomas acesso restrito busca dia 23 do mês 11 novembro ano 2023 assunto Neoplasms fao clínica Oral and oropharyngeal diffuse large b-cell lymphoma and high-grade b-cell lymphoma: a clinicopathologic and prognostic study of 69 casespt_BR
dc.subjectneoplasias de cabeça e pescoço título periódico: Oral surgery oral medicine oral pathology oral radiologypt_BR
dc.subject.otherLymphoma, large B-Cell, diffusept_BR
dc.subject.otherImmunohistochemistrypt_BR
dc.subject.otherNeoplasmspt_BR
dc.subject.otherSurvival ratept_BR
dc.subject.otherEpstein-Barr virus infectionspt_BR
dc.subject.otherNecrosispt_BR
dc.subject.otherPrognosispt_BR
dc.titleOral and oropharyngeal diffuse large B-Cell lymphoma and high-grade B-Cell lymphoma: a clinicopathologic and prognostic study of 69 casespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S2212440320313328?via%3Dihubpt_BR
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