Use este identificador para citar ou linkar para este item: http://hdl.handle.net/1843/61661
Tipo: Artigo de Periódico
Título: Oral and oropharyngeal diffuse large B-Cell lymphoma and high-grade B-Cell lymphoma: a clinicopathologic and prognostic study of 69 cases
Autor(es): Carla Isabelly Rodrigues-Fernandes
Débora Lima Pereira
Luis Fernando Rivero
Kelly Tambasco Bezerra
Bruno Augusto Benevenuto de Andrade
Mário José Romañach
Michele Agostini
Javier Rendón Henao
Amanda de Farias Gabriel
Décio dos Santos Pinto Júnior
Manoela Domingues Martins
Arnaldo Gonçalves Junior
Mateus José de Carvalho Pereira
Ricardo Alves Mesquita
Ricardo Santiago Gomez
Giovanna Ribeiro Souto
Alan Roger Santos-Silva
Pablo Agustin Vargas
Márcio Ajudarte Lopes
Oslei Paes de Almeida
Flávia Sirotheau Corrêa Pontes
Hélder Antônio Rebelo Pontes
Ciro Dantas Soares
Rommel Mario Rodríguez Burbano
Felipe Paiva Fonseca
Thayná Melo de Lima Morais
Gleyson Kleber do Amaral-Silva
Maria Goretti Freire de Carvalho
Lucas Lacerda de Souza
Fábio Ramôa Pires
Teresa Cristina Ribeiro Bartholomeu dos Santos
Resumo: Objective: The objective of this study was to describe the clinicopathological, molecular, and prognostic features of oral/oropharyngeal diffuse large B-cell lymphoma (DLBCL) and high-grade B-cell lymphoma. Study design: All cases were retrieved from 7 Brazilian institutions. Immunohistochemical reactions were performed to confirm the diagnoses and to categorize the tumors. In situ hybridization was used to detect Epstein-Barr virus (EBV) and fluorescence in situ hybridization was used to identify gene rearrangements. Results: Most cases involved the oral cavity (76.8%). Males and females, with a mean age of 60 years, were evenly affected. Tumors mostly presented as painful swellings. Forty cases represented germinal center B-cell type (58%). Five cases presented double-hit translocation and 3 harbored rearrangement for MYC/BCL2/BCL6. EBV was detected in 3 cases (4.3%). The 5-year overall survival was 44.4%. Female sex, presence of pain and ulcer, microscopic "starry sky pattern" and necrosis, co-expression of c-Myc/Bcl2, and translocation of MYC were associated with a lower survival in univariate analysis (P = .05, P = .01, P = .01, P = .03, P = .05, P = .006, P = .05, respectively). Conclusion: Patients affected by oral/oropharyngeal DLBCL have a low survival rate. High-grade B-cell lymphoma (17.7%) and EBV-positive DLBCL, not otherwise specified (4.3%) account for a small number of cases.
Assunto: Lymphoma, large B-Cell, diffuse
Immunohistochemistry
Neoplasms
Survival rate
Epstein-Barr virus infections
Necrosis
Prognosis
Idioma: eng
País: Brasil
Editor: Universidade Federal de Minas Gerais
Sigla da Instituição: UFMG
Departamento: FAO - DEPARTAMENTO DE CLÍNICA
Tipo de Acesso: Acesso Restrito
Identificador DOI: https://doi.org/10.1016/j.oooo.2020.11.005
URI: http://hdl.handle.net/1843/61661
Data do documento: Abr-2021
metadata.dc.url.externa: https://www.sciencedirect.com/science/article/pii/S2212440320313328?via%3Dihub
metadata.dc.relation.ispartof: Oral Surgery Oral Medicine Oral Pathology Oral Radiology
Aparece nas coleções:Artigo de Periódico

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