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http://hdl.handle.net/1843/61671| Type: | Artigo de Periódico |
| Title: | Nanofibers containing tetracycline/β-cyclodextrin: physico-chemical characterization and antimicrobial evaluation |
| Authors: | Ana Paula de Figueiredo Monteiro Cíntia M. S. L. Rocha Michele Fabiane de Oliveira Sávio Morato Lacerda Gontijo Ricardo Ramírez-Agudelo Rubén Dario Sinisterra Millán María Esperanza Cortés Segura |
| Abstract: | This study aimed to compare two nanofiber drug delivery systems that were prepared with an electrospun process and have the potential to serve as adjuvants for the treatment of periodontal disease. The first system was composed of polycaprolactone loaded with tetracycline (TCN) and the second was composed of polycaprolactone loaded with tetracycline/β-cyclodextrin (TCN:BCD). An antimicrobial diffusion test was performed for each of these sets of nanofibers with the microorganisms, Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, both of which contribute to periodontal disease. In vitro release profiles were also obtained, and the nanofibers were characterized by thermal analysis, x-ray powder diffraction, infrared absorption spectroscopy, and scanning electron microscopy. Profiles of the TCN and TCN:BCD nanofibers showed that drug release occurred for up to 14 days. However, the TCN:BCD nanofibers appeared to better protect and enhance the biological absorption of TCN due to theformation of a TCN:BCD inclusion complex. |
| Subject: | Tetraciclina Ciclodextrinas Materiais nanoestruturados Agentes antiinfecciosos Físico-química Sistemas de distribuição de medicamentos Sistemas deliberados de drogas poliméricas Doença periodontal Análise térmica Raios X - Difração Fourier, Espectroscopia de infravermelho por transformada de Microscopia eletrônica de varredura Química farmacêutica |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | http://dx.doi.org/10.1016/j.carbpol.2016.09.059 |
| URI: | http://hdl.handle.net/1843/61671 |
| Issue Date: | Jan-2017 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0144861716311134 |
| metadata.dc.relation.ispartof: | Carbohydrate Polymers |
| Appears in Collections: | Artigo de Periódico |
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