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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61671
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dc.creatorAna Paula de Figueiredo Monteiropt_BR
dc.creatorCíntia M. S. L. Rochapt_BR
dc.creatorMichele Fabiane de Oliveirapt_BR
dc.creatorSávio Morato Lacerda Gontijopt_BR
dc.creatorRicardo Ramírez-Agudelopt_BR
dc.creatorRubén Dario Sinisterra Millánpt_BR
dc.creatorMaría Esperanza Cortés Segurapt_BR
dc.date.accessioned2023-12-04T13:47:31Z-
dc.date.available2023-12-04T13:47:31Z-
dc.date.issued2017-01-
dc.citation.volume156pt_BR
dc.citation.spage417pt_BR
dc.citation.epage426pt_BR
dc.identifier.doihttp://dx.doi.org/10.1016/j.carbpol.2016.09.059pt_BR
dc.identifier.issn1879-1344pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61671-
dc.description.resumoThis study aimed to compare two nanofiber drug delivery systems that were prepared with an electrospun process and have the potential to serve as adjuvants for the treatment of periodontal disease. The first system was composed of polycaprolactone loaded with tetracycline (TCN) and the second was composed of polycaprolactone loaded with tetracycline/β-cyclodextrin (TCN:BCD). An antimicrobial diffusion test was performed for each of these sets of nanofibers with the microorganisms, Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, both of which contribute to periodontal disease. In vitro release profiles were also obtained, and the nanofibers were characterized by thermal analysis, x-ray powder diffraction, infrared absorption spectroscopy, and scanning electron microscopy. Profiles of the TCN and TCN:BCD nanofibers showed that drug release occurred for up to 14 days. However, the TCN:BCD nanofibers appeared to better protect and enhance the biological absorption of TCN due to theformation of a TCN:BCD inclusion complex.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofCarbohydrate Polymerspt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectTetracyclinept_BR
dc.subjectCyclodextrinpt_BR
dc.subjectInclusion compoundpt_BR
dc.subjectNanofiberspt_BR
dc.subjectAntimicrobial activitypt_BR
dc.subjectElectrospunapt_BR
dc.subject.otherTetraciclinapt_BR
dc.subject.otherCiclodextrinaspt_BR
dc.subject.otherMateriais nanoestruturadospt_BR
dc.subject.otherAgentes antiinfecciosospt_BR
dc.subject.otherFísico-químicapt_BR
dc.subject.otherSistemas de distribuição de medicamentospt_BR
dc.subject.otherSistemas deliberados de drogas poliméricaspt_BR
dc.subject.otherDoença periodontalpt_BR
dc.subject.otherAnálise térmicapt_BR
dc.subject.otherRaios X - Difraçãopt_BR
dc.subject.otherFourier, Espectroscopia de infravermelho por transformada dept_BR
dc.subject.otherMicroscopia eletrônica de varredurapt_BR
dc.subject.otherQuímica farmacêuticapt_BR
dc.titleNanofibers containing tetracycline/β-cyclodextrin: physico-chemical characterization and antimicrobial evaluationpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0144861716311134pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4202-1964pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7803-4345pt_BR
dc.identifier.orcidhttps://orcid.org/0009-0001-5010-7450pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7656-1849pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0560-8491pt_BR
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