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http://hdl.handle.net/1843/61671
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DC Field | Value | Language |
---|---|---|
dc.creator | Ana Paula de Figueiredo Monteiro | pt_BR |
dc.creator | Cíntia M. S. L. Rocha | pt_BR |
dc.creator | Michele Fabiane de Oliveira | pt_BR |
dc.creator | Sávio Morato Lacerda Gontijo | pt_BR |
dc.creator | Ricardo Ramírez-Agudelo | pt_BR |
dc.creator | Rubén Dario Sinisterra Millán | pt_BR |
dc.creator | María Esperanza Cortés Segura | pt_BR |
dc.date.accessioned | 2023-12-04T13:47:31Z | - |
dc.date.available | 2023-12-04T13:47:31Z | - |
dc.date.issued | 2017-01 | - |
dc.citation.volume | 156 | pt_BR |
dc.citation.spage | 417 | pt_BR |
dc.citation.epage | 426 | pt_BR |
dc.identifier.doi | http://dx.doi.org/10.1016/j.carbpol.2016.09.059 | pt_BR |
dc.identifier.issn | 1879-1344 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/1843/61671 | - |
dc.description.resumo | This study aimed to compare two nanofiber drug delivery systems that were prepared with an electrospun process and have the potential to serve as adjuvants for the treatment of periodontal disease. The first system was composed of polycaprolactone loaded with tetracycline (TCN) and the second was composed of polycaprolactone loaded with tetracycline/β-cyclodextrin (TCN:BCD). An antimicrobial diffusion test was performed for each of these sets of nanofibers with the microorganisms, Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, both of which contribute to periodontal disease. In vitro release profiles were also obtained, and the nanofibers were characterized by thermal analysis, x-ray powder diffraction, infrared absorption spectroscopy, and scanning electron microscopy. Profiles of the TCN and TCN:BCD nanofibers showed that drug release occurred for up to 14 days. However, the TCN:BCD nanofibers appeared to better protect and enhance the biological absorption of TCN due to theformation of a TCN:BCD inclusion complex. | pt_BR |
dc.description.sponsorship | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico | pt_BR |
dc.description.sponsorship | FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais | pt_BR |
dc.description.sponsorship | CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior | pt_BR |
dc.description.sponsorship | INCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio) | pt_BR |
dc.language | eng | pt_BR |
dc.publisher | Universidade Federal de Minas Gerais | pt_BR |
dc.publisher.country | Brasil | pt_BR |
dc.publisher.department | FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA | pt_BR |
dc.publisher.department | ICX - DEPARTAMENTO DE QUÍMICA | pt_BR |
dc.publisher.initials | UFMG | pt_BR |
dc.relation.ispartof | Carbohydrate Polymers | pt_BR |
dc.rights | Acesso Restrito | pt_BR |
dc.subject | Tetracycline | pt_BR |
dc.subject | Cyclodextrin | pt_BR |
dc.subject | Inclusion compound | pt_BR |
dc.subject | Nanofibers | pt_BR |
dc.subject | Antimicrobial activity | pt_BR |
dc.subject | Electrospuna | pt_BR |
dc.subject.other | Tetraciclina | pt_BR |
dc.subject.other | Ciclodextrinas | pt_BR |
dc.subject.other | Materiais nanoestruturados | pt_BR |
dc.subject.other | Agentes antiinfecciosos | pt_BR |
dc.subject.other | Físico-química | pt_BR |
dc.subject.other | Sistemas de distribuição de medicamentos | pt_BR |
dc.subject.other | Sistemas deliberados de drogas poliméricas | pt_BR |
dc.subject.other | Doença periodontal | pt_BR |
dc.subject.other | Análise térmica | pt_BR |
dc.subject.other | Raios X - Difração | pt_BR |
dc.subject.other | Fourier, Espectroscopia de infravermelho por transformada de | pt_BR |
dc.subject.other | Microscopia eletrônica de varredura | pt_BR |
dc.subject.other | Química farmacêutica | pt_BR |
dc.title | Nanofibers containing tetracycline/β-cyclodextrin: physico-chemical characterization and antimicrobial evaluation | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.url.externa | https://www.sciencedirect.com/science/article/pii/S0144861716311134 | pt_BR |
dc.identifier.orcid | https://orcid.org/0000-0002-4202-1964 | pt_BR |
dc.identifier.orcid | https://orcid.org/0000-0002-7803-4345 | pt_BR |
dc.identifier.orcid | https://orcid.org/0009-0001-5010-7450 | pt_BR |
dc.identifier.orcid | https://orcid.org/0000-0001-7656-1849 | pt_BR |
dc.identifier.orcid | https://orcid.org/0000-0002-0560-8491 | pt_BR |
Appears in Collections: | Artigo de Periódico |
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