1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61802
Full metadata record
DC FieldValueLanguage
dc.creatorDaniel Albuquerque Terrapt_BR
dc.creatorEduardo Garcia Vilelapt_BR
dc.creatorRodrigo Otávio Silveira Silvapt_BR
dc.creatorLlaiane Alves Leãopt_BR
dc.creatorKarine Sampaio Limapt_BR
dc.creatorEdward j. Kuijperpt_BR
dc.creatorRaissa Iglesias Fernandes Ângelo Passospt_BR
dc.creatorLuiz Gonzaga Vaz Coelhopt_BR
dc.date.accessioned2023-12-06T19:28:08Z-
dc.date.available2023-12-06T19:28:08Z-
dc.date.issued2022-12-07-
dc.citation.volume4pt_BR
dc.citation.issue4pt_BR
dc.citation.spagee806pt_BR
dc.citation.epage12pt_BR
dc.identifier.doihttps://doi/10.26355/mhd_202212_806pt_BR
dc.identifier.issn2704-8845pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61802-
dc.description.resumoIntroduction: Clostridioides difficile infection (CDI) is a major cause of nosocomial diarrhea related to the use of antimicrobials worldwide. Treatment of recurrent CDI is challenging in countries where fecal microbiota transplantation (FMT) is not widely available. Furthermore, data on the effectiveness and safety of FMT in emerging countries are scarce. Thus, this study aimed to describe the initial experience of the first fecal microbiota transplantation center in Brazil for the treatment of recurrent CDI using frozen samples. Materials and Methods: FMT was performed via colonoscopy using frozen samples from a stool bank. Donors were screened according to international guidelines and national regulatory resolutions. CDI diagnosis was confirmed in all patients. FMT success was defined as cessation of diarrhea within eight weeks. C. difficile isolates were subjected to ribotyping and antimicrobial susceptibility testing. Results: Over two years, ten patients with recurrent CDI underwent FMT. The median age was 68 years (range: 23-87 years), 70% were women, 60% had severe infection. Furthermore, a median of 3 previous CDI episodes (range: 1-4) was observed. The primary resolution with a single FMT was 80%, while the overall resolution after the second FMT was 90%. Failure of treatment was not related to CDI severity (p = 0.273), bowel preparation (p = 0.345), comorbidities (p = 0.809), or number of previous episodes (p = 0.457). No serious adverse events were described during the follow-up of 26.6 months (range: 26.6-38.2 months). Mild adverse events occurred in 54.5% of the cases, which was mainly abdominal discomfort on the first day after the procedure. In addition, toxigenic C. difficile isolates belonged to ribotypes 106, 014/020, 131, 076, and 037. All the isolates were susceptible to metronidazole and vancomycin. Conclusions: FMT is a safe and effective treatment for recurrent CDI in this cohort of Brazilian patients. The implementation of a stool bank allowed for the proper application of all the requirements needed to perform FMT in the country.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentMEDICINA - FACULDADE DE MEDICINApt_BR
dc.publisher.departmentVET - DEPARTAMENTO DE MEDICINA VETERINÁRIA PREVENTIVApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofMicrobiota in Health and Diseasept_BR
dc.rightsAcesso Abertopt_BR
dc.subjectFecal microbiota transplantationpt_BR
dc.subjectClostridioides difficile infectionpt_BR
dc.subjectStool bankpt_BR
dc.subjectRibotypespt_BR
dc.subject.otherTransplante de Microbiota Fecalpt_BR
dc.subject.otherInfecções por Clostridiumpt_BR
dc.subject.otherRibotipagempt_BR
dc.titleExperience of the first Brazilian fecal microbiota transplantation center in treating recurrent Clostridioides difficile infectionpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.microbiotajournal.com/article/806pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
File Description SizeFormat 
Experience of the first Brazilian fecal microbiota transplantation center in treating recurrent Clostridioides difficile infection.pdf629.69 kBAdobe PDFView/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.