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http://hdl.handle.net/1843/61821| Type: | Artigo de Periódico |
| Title: | Salivary gland cancer in southern Brazil: a prognostic study of 107 cases |
| Authors: | Virgilio Gonzales Zanella Pablo Agustin Vargas Manoela Domingues Martins Vivian Petersen Wagner Tuany Rafaeli Schmidt Stefanie Thieme Cintia Correa Felipe Paiva Fonseca Pettala Rigon Marinez Bizarro Barra Ricardo Gallicchio Kroef |
| Abstract: | Background: Salivary gland cancers (SGC) represent an uncommon group of heterogeneous tumors. We performed a retrospective survey of SGC diagnosed in a reference center for treatment of malignant tumors from the south of Brazil aiming to determine the prognostic value of demographic, clinic and pathologic features. Material and methods: Cases diagnosed as SGC between 2006 and 2016 were retrospectively collected. Medical records were examined to extract demographic, clinic, pathologic and follow-up information. Results: One-hundred and seven cases of SGC were identified. The most common SGC were mucoepidermoid carcinoma (MEC) (n = 39) followed by adenoid cystic carcinoma (AdCC) (n = 29). Among AdCCs, 55.2% of cases were classified as cribriform, 27.6% as tubular and 17.2% as solid. The tubular subtype had the highest percentage of cases with perineural invasion (p=0.01). Among MEC, 61.5% of cases were classified as low grade, 15.4% as intermediate grade and 19.9% as high grade. Low grade MEC had the lowest percentage of cases with perineural invasion (p=0.04). The 5-year survival for loco-regional control, disease-free survival (DFS) and disease-specific survival were 75%, 70% and 84%, respectively. The following features were associated with poor DFS: advanced age (p=0.03), rural residency (p=0.01), being a smoker or former smoker (p=0.01), pain (p=0.03), nodal metastasis (p<0.001), need for chemotherapy (p=0.02), neck dissection (p=0.04), perineural invasion (p=0.01), and being diagnosed with AdCC compared to MEC (p=0.02). Conclusions: The clinco-demographic and pathologic features identified as prognostic factors reveal the profile of patients at increased risk of recurrence and who would benefit from closer follow-up. |
| Subject: | Head and neck neoplasms Epithelial cells Rare diseases Epidemiology Prognosis Recurrence Carcinoma Survival |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.4317%2Fmedoral.24248 |
| URI: | http://hdl.handle.net/1843/61821 |
| Issue Date: | 28-Nov-2020 |
| metadata.dc.url.externa: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141320/ |
| metadata.dc.relation.ispartof: | Medicina Oral Patologia Oral y Cirugia Bucal |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Salivary gland cancer in Southern Brazil a prognostic study of 107 cases.pdf | 2.32 MB | Adobe PDF | View/Open |
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