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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61825
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dc.creatorAlexandre Rodriguesferreirapt_BR
dc.creatorThaís Costa Nascentes Queirozpt_BR
dc.creatorPaula Vieira Teixeira Vidigalpt_BR
dc.creatorRaquel di Paula Ferreirapt_BR
dc.creatorDavid Campos Wanderleypt_BR
dc.creatorEleonora Druve Tavares Fagundespt_BR
dc.date.accessioned2023-12-06T21:40:53Z-
dc.date.available2023-12-06T21:40:53Z-
dc.date.issued2019-
dc.citation.volume56pt_BR
dc.citation.issue1pt_BR
dc.citation.spage71pt_BR
dc.citation.epage78pt_BR
dc.identifier.doi10.1590/s0004-2803.201900000-18pt_BR
dc.identifier.issn16784219pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61825-
dc.description.resumoABSTRACT – Background – Biliary atresia represents the most common surgically treatable cause of cholestasis in newborns. If not corrected, secondary biliary cirrhosis invariably results. Objective – To evaluate, through multivariate analysis, the prognostic factors associated with the presence of biliary flow and survival with the native liver following Kasai portoenterostomy. Methods – The study analyzed data from 117 biliary atresia patients who underwent portoenterostomy and had suitable histological material for evaluation. A logistic regression model was used to assess the presence of biliary flow. Survival was investigated through Kaplan-Meier curves and Cox-adjusted models. Results – One third of patients achieved biliary flow and the median age at surgery was 81 days. Age at surgery, albumin, postoperative complications, biliary atresia structural malformation (BASM), liver architecture, larger duct diameter at porta hepatis, and cirrhosis (Ishak score) were the initial variables for the multivariate analysis. Age at surgery >90 days was the only variable associated with the absence of biliary drainage. Survival analysis revealed that the absence of biliary flow (P<0.0001), age at surgery >90 days (P=0.035), and the presence of BASM (P<0.0001), alone, could predict death or need for liver transplantation. Multivariate analysis demonstrated that the absence of biliary flow (P<0.0001 hazard ratio [HR] 6.25, 95% confidence interval [CI] 3.19–12.22) and the presence of BASM (P=0.014 HR 2.16, 95% CI 1.17–3.99) were associated with lowest survival with the native liver. Conclusion – Age at surgery >90 days was associated with absence of biliary flow. The presence of biliary drainage and the absence of structural malformations are cornerstone features for higher survival rates with the native liver.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGALpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofArquivos de Gastroenterologia-
dc.rightsAcesso Abertopt_BR
dc.subjectBiliary Atresiapt_BR
dc.subjectCholestasispt_BR
dc.subjectNewborn infantpt_BR
dc.subjectPrognosispt_BR
dc.subjectLiver transplantationpt_BR
dc.subjectPortoenterostomy, Hepaticpt_BR
dc.subject.otherBiliary Atresiapt_BR
dc.subject.otherCholestasispt_BR
dc.subject.otherInfant, Newbornpt_BR
dc.subject.otherPrognosispt_BR
dc.subject.otherLiver Transplantationpt_BR
dc.subject.otherPortoenterostomy, Hepaticpt_BR
dc.titleMultivariate analysis of biliary flow-related factors and post-kasai survival in biliary atresia patientspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://doi.org/10.1590/S0004-2803.201900000-18pt_BR
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