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http://hdl.handle.net/1843/61856| Type: | Artigo de Periódico |
| Title: | Edaravone inhibits the production of reactive oxygen species in phagocytosis- and pkc-stimulated granulocytes from multiple sclerosis patients edaravone modulate oxidative stress in multiple sclerosis |
| Authors: | Pedro Henrique Villar-Delfino Nathália Augusta Oliveira Gomes Paulo Pereira Christo José Augusto Nogueira-Machado Caroline Maria Oliveira Volpe |
| Abstract: | BACKGROUND: Oxidative stress is associated with the pathogenesis of MS. Edaravone (EDV) has been proposed as a therapeutic resource for central nervous system diseases, and it was effective in reducing oxidative stress. However, the antioxidant mechanisms of EDV are poorly studied. OBJECTIVE: This study aimed to evaluate the effects of EDV on resting, phagocytosis, and PKC-activated granulocytes derived from MS patients and a healthy control group. METHODS: The effects of EDV on ROS production in phagocytosis (ROS production in the presence of opsonized particles) and PKC-stimulated granulocytes were evaluated in a luminol-dependent chemiluminescence method. Calphostin C was used in some experiments to compare with those of EDV. RESULTS: EDV inhibited ROS production in phagocytosis of opsonized particles and PKC-stimulated granulocytes from MS patients and healthy control group. In the presence of calphostin C, the inhibition of ROS production was similar to that observed with EDV. CONCLUSION: These findings suggest the involvement of EDV on the ROS-PKC-NOX signaling pathways modulating oxidative stress in MS. EDV represents a promising treatment option to control oxidative innate immune response for MS. KEYWORDS: edaravone, multiple sclerosis, innate immunity, reactive oxygen species, phagocytosis, protein kinase C. |
| Subject: | Edaravone Esclerose Múltipla Estresse Oxidativo |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1177/11795735221092524 |
| URI: | http://hdl.handle.net/1843/61856 |
| Issue Date: | 2022 |
| metadata.dc.url.externa: | https://journals.sagepub.com/doi/10.1177/11795735221092524 |
| metadata.dc.relation.ispartof: | Journal of Central Nervous System Disease |
| Appears in Collections: | Artigo de Periódico |
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