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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61869
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dc.creatorDeborah Fernandes Rodriguespt_BR
dc.creatorRenê Oliveira do Coutopt_BR
dc.creatorRubén Dario Sinisterra Millánpt_BR
dc.creatorCarlos Eduardo de Matos Jensenpt_BR
dc.date.accessioned2023-12-11T15:19:06Z-
dc.date.available2023-12-11T15:19:06Z-
dc.date.issued2020-
dc.citation.volume56pt_BR
dc.identifier.doihttps://doi.org/10.1590/s2175-97902019000418363pt_BR
dc.identifier.issn2175-9790pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61869-
dc.description.resumoThis paper reports on the development of nanoparticles aiming at the in vitro controlled release of simvastatin (SVT). The nanoparticles were prepared by the nanoprecipitation method with polymers Eudragit® FS30D (EDGFS) or Eudragit® NE30D (EDGNE). EDGFS+SVT nanoparticles showed mean size of 148.8 nm and entrapment efficiency of 76.4%, whereas EDGNE+SVT nanoparticles showed mean size of 105.0 nm and entrapment efficiency of 103.2%. Infrared absorption spectra demonstrated that SVT incorporated into the polymer matrix, especially EDGNE. Similarly, the differential scanning calorimeter (DSC) curve presented no endothermic peak of fusion, indicating that the system is amorphous and the drug is not in the crystalline state. The maintenance of SVT in the amorphous state may favors its solubilization in the target release sites. In the in vitro dissolution assay, the SVT incorporated into the EDGFS+SVT nanoparticles showed a rapid initial release, which may be related to the pH of the dissolution medium used. Regarding the EDGNE+SVT nanoparticles, the in vitro release occurred in a bimodal behavior, i.e., an initial “burst” followed by a sustained delivery, with the kinetics of drug release following Baker-Lonsdale’s mathematical model. All these features suggest the nanoparticulate system’s potential to modulate SVT delivery and enhance its bioavailability.pt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciences-
dc.rightsAcesso Abertopt_BR
dc.subjectSimvastatinpt_BR
dc.subjectNanoparticlespt_BR
dc.subjectPoly-methylmethacrylatept_BR
dc.subjectDissolutionpt_BR
dc.subjectDrug delivery systemspt_BR
dc.subject.otherQuímica farmacêuticapt_BR
dc.subject.otherPolímeros na medicinapt_BR
dc.subject.otherMedicamentos -- Biodisponibilidadept_BR
dc.subject.otherMedicamentos -- Dissoluçãopt_BR
dc.subject.otherEstatinas (Agentes cardiovasculares)pt_BR
dc.subject.otherSistemas de distribuição de medicamentospt_BR
dc.subject.otherNanopartículaspt_BR
dc.titleNovel Eudragit® -based polymeric nanoparticles for sustained release of simvastatinpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/bjps/a/VHzcCPtQRBdQDFhQtxT7kLq/pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1406-0007pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3748-3427pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7656-1849pt_BR
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