1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61924
Full metadata record
DC FieldValueLanguage
dc.creatorGiselle Santos Magalhãespt_BR
dc.creatorJuliana Fabiana Gregóriopt_BR
dc.creatorArthur Tonani Pereira Cançado Ribeiropt_BR
dc.creatorIsis Felippe Baronipt_BR
dc.creatorAna Victoria de Oliveira Vasconcellospt_BR
dc.creatorGabriela Pansanato Nakashimapt_BR
dc.creatorIsabel Fusaro Aguiar Oliveirapt_BR
dc.creatorNatália Alves de Matospt_BR
dc.creatorThalles de Freitas Castropt_BR
dc.creatorFrank Silva Bezerrapt_BR
dc.creatorRubén Dario Sinisterra Millánpt_BR
dc.creatorVanessa Pinhopt_BR
dc.creatorMauro Martins Teixeirapt_BR
dc.creatorRobson Augusto Souza Santospt_BR
dc.creatorMaria da Glória Rodrigues-Machadopt_BR
dc.creatorMaria José Campagnole dos Santospt_BR
dc.date.accessioned2023-12-12T17:49:29Z-
dc.date.available2023-12-12T17:49:29Z-
dc.date.issued2021-
dc.citation.volume12pt_BR
dc.identifier.doihttps://doi.org/10.3389/fphar.2021.557962pt_BR
dc.identifier.issn1663-9812pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/61924-
dc.description.resumoThe presence of eosinophils and neutrophils in the lungs of asthmatic patients is associated with the severity of the disease and resistance to corticosteroids. Thus, defective resolution of eosinophilic and neutrophilic inflammation is importantly related to exacerbation of asthma. In this study, we investigated a therapeutic action of angiotensin-(1-7) (Ang-(1-7)) in a model of asthma induced by ovalbumin (OVA) and lipopolysaccharide (LPS). Balb-c mice were sensitized and challenged with OVA. Twenty-three hours after the last OVA challenge, experimental groups received LPS, and 1 h and 7 h later, mice were treated with oral formulation of Ang-(1-7). On the next day, 45 h after the last challenge with OVA, mice were subjected to a test of motor and exploratory behavior; 3 h later, lung function was evaluated, and bronchoalveolar lavage fluid (BALF) and lungs were collected. Motor and exploratory activities were lower in OVA + LPS-challenged mice. Treatment with Ang-(1-7) improved these behaviors, normalized lung function, and reduced eosinophil, neutrophil, myeloperoxidase (MPO), eosinophilic peroxidase (EPO), and ERK1/2 phosphorylation (p-ERK1/2) in the lungs. In addition, Ang-(1-7) decreased the deposition of mucus and extracellular matrix in the airways. These results extended those of previous studies by demonstrating that oral administration of Ang-(1-7) at the peak of pulmonary inflammation can be valuable for the treatment of neutrophil- and eosinophil-mediated asthma. Therefore, these findings potentially provide a new drug to reverse the natural history of the disease, unlike the current standards of care that manage the disease symptoms at best.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofFrontiers in Pharmacologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectResolution of inflammationpt_BR
dc.subjectEosinophilic inflammationpt_BR
dc.subjectNeutrophilic inflammationpt_BR
dc.subjectAllergic lung inflammationpt_BR
dc.subjectLPSpt_BR
dc.subjectRenin–angiotensin system 4pt_BR
dc.subject.otherFarmacologia pulmonarpt_BR
dc.subject.otherAngiotensinapt_BR
dc.subject.otherAsmapt_BR
dc.subject.otherEosinófilospt_BR
dc.subject.otherNeutrófilospt_BR
dc.subject.otherAparelho respiratório -- Doençaspt_BR
dc.titleOral formulation of angiotensin-(1-7) promotes therapeutic actions in a model of eosinophilic and neutrophilic asthmapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.frontiersin.org/articles/10.3389/fphar.2021.557962/fullpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2589-0332pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1032-4255pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6119-6049pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4486-1518pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5568-5997pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2535-2737pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8102-7720pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0804-5196pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7656-1849pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1038-2324pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6944-3008pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9950-1707pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9483-4206pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
File Description SizeFormat 
Oral formulation of angiotensin-(1-7) promotes therapeutic actions in a model of eosinophilic and neutrophilic asthma.pdf732.11 kBAdobe PDFView/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.