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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/62433
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dc.creatorMarina Lopes Castropt_BR
dc.creatorBruna Maia Cerqueira Câmarapt_BR
dc.creatorMaira Souza Oliveira Barretopt_BR
dc.creatorRaphael Rocha Wenceslaupt_BR
dc.creatorAndressa Karollini e Silvapt_BR
dc.creatorNatália Fagundespt_BR
dc.creatorRenata Andrade Silvapt_BR
dc.creatorEutálio Luiz Mariani Pimentapt_BR
dc.creatorSuzane Lilian Beierpt_BR
dc.date.accessioned2024-01-03T16:42:32Z-
dc.date.available2024-01-03T16:42:32Z-
dc.date.issued2022-11-24-
dc.citation.volume2022pt_BR
dc.citation.spage9613721pt_BR
dc.citation.epage16pt_BR
dc.identifier.doihttps://doi.org/10.1155/2022/9613721pt_BR
dc.identifier.issn1687-6970pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/62433-
dc.description.resumoObjectives. The aim of the study is to compare the sedative, cardiorespiratory, echocardiographic, and blood gas effects of dexmedetomidine and methadone associated or not with midazolam for restraint chemistry in cats. Methods. Eighteen healthy young cats (4.06 ± 0.48 kg) were randomly sedated with two protocols, through the intramuscular route: dexmedetomidine (5 µg.kg−1), methadone (0.3 mg. kg−1) and midazolam (0.3 mg. kg−1) (DMTM, n = 9), or dexmedetomidine (7.5 µg.kg−1) and methadone (0.3 mg. kg−1) (DMT, n = 9). The cardiorespiratory parameters were measured at baseline, 5 and 10 minutes after pharmacological latency. The sedation, analgesia, and muscle relaxation scores were assessed before and 5 minutes after pharmacological latency, while arterial blood gas analysis and echocardiography were assessed before and after 10 or 15 minutes, respectively. Results. There was no difference between the protocols regarding the cardiorespiratory, blood gas, and echocardiographic parameters used. The scores for sedation, analgesia, and muscle relaxation also did not differ between the protocols, with the degree of sedation, analgesia, and myorelaxation considered satisfactory in both groups. A significant decrease in heart rate (HR) was observed after administration of the sedative protocols, reaching a maximum reduction at T10 (46% and 53% reduction in the DMT and DMTM groups, respectively). The reduction in HR had an impact on echocardiographic parameters such as CO, which decreased 53% and 56% in the DMT and DMTM groups, respectively. There was a significant reduction in PaO2, SaO2, ejection fraction, and fractional shortening in both protocols. SpO2 decreased significantly after 5 minutes of sedation in the DMT group, but with a minimum mean SpO2 of 92% in T5. The respiratory rate decreased significantly at 5 and 10 minutes in the DMTM group, while PaCO2 increased in both groups, indicating respiratory depression caused by the drugs. Conclusions and Relevance. The study pointed out that both sedative protocols can be recommended for clinical sedation of young and healthy cats in the doses used. However, both protocols resulted in cardiorespiratory depression in cats and also the particularities of the animals should be evaluated regarding reducing cardiac output by more than 50%.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentVET - DEPARTAMENTO DE CLÍNICA E CIRURGIApt_BR
dc.publisher.departmentVET - DEPARTAMENTO DE ZOOTECNIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAnesthesiology Research and Practicept_BR
dc.rightsAcesso Abertopt_BR
dc.subjectDexmedetomidinapt_BR
dc.subjectMidazolampt_BR
dc.subjectGatospt_BR
dc.subjectHemodinâmicapt_BR
dc.subject.otherDexmedetomidinapt_BR
dc.subject.otherMidazolampt_BR
dc.subject.otherGatospt_BR
dc.subject.otherHemodinâmicapt_BR
dc.titleEffect of Dexmedetomidine Low Doses with or without Midazolam in Cats: Clinical, Hemodynamic, Blood Gas Analysis, and Echocardiographic Effectspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.hindawi.com/journals/arp/2022/9613721/pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0616-3559pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3501-611Xpt_BR
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