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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/62555
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dc.creatorGermano Carneirocostapt_BR
dc.creatorManoel Otávio da Costa Rochapt_BR
dc.creatorPaulo Eduardo Alencar de Souzapt_BR
dc.creatorDiego Felipe sa Melopt_BR
dc.creatorPaula Rocha Moreirapt_BR
dc.creatorKenneth John Gollobpt_BR
dc.creatorMaria do Carmo Pereira Nunespt_BR
dc.creatorWalderez Ornelas Dutrapt_BR
dc.date.accessioned2024-01-10T21:08:30Z-
dc.date.available2024-01-10T21:08:30Z-
dc.date.issued2020-
dc.citation.volume115pt_BR
dc.citation.issuee200110pt_BR
dc.citation.spage1pt_BR
dc.citation.epage5pt_BR
dc.identifier.doi10.1590/0074-02760200110pt_BR
dc.identifier.issn16788060pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/62555-
dc.description.resumoChagas disease cardiomyopathy is the most severe outcome of the infection with the protozoan Trypano soma cruzi, responsible for over 10,000 deaths annually. There are currently over 100 million people at risk of infection with T. cruzi and, of those, at least 30% may develop the deadly cardiomyopathy. There is no vaccine to prevent the disease and no markers to identify indi viduals at risk of developing the severe form. The great clinical variability of chronic Chagas disease is directly associated with the host’s immune response.(1,2) Research from our group has previously shown that CD14+ monocytes are critical cells in determining the inflammatory and anti-inflammatory immunological profile observed in chronic cardiac and asymptomatic (indeterminate) Chagas patients, respectively.(1) In addition, T. cruzi strains have been associated with severe and mild infections and profoundly affect the response of CD14+ monocytes, inducing an inflammatory or regula tory profile in these cells, respectively.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofMemórias do Instituto Oswaldo Cruz-
dc.rightsAcesso Abertopt_BR
dc.subjectChagas cardiomyopathypt_BR
dc.subjectCD14pt_BR
dc.subjectPolymorphismpt_BR
dc.subject.otherChagas cardiomyopathypt_BR
dc.subject.otherLipopolysaccharide Receptorspt_BR
dc.titleCd14 genotype and functional dichotomy of cd14+ and cd14- cells are associated with activated immune response and development of chagas dilated cardiomyopathypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externadoi:10.1590/0074-02760200110pt_BR
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