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http://hdl.handle.net/1843/62555| Type: | Artigo de Periódico |
| Title: | Cd14 genotype and functional dichotomy of cd14+ and cd14- cells are associated with activated immune response and development of chagas dilated cardiomyopathy |
| Authors: | Germano Carneirocosta Manoel Otávio da Costa Rocha Paulo Eduardo Alencar de Souza Diego Felipe sa Melo Paula Rocha Moreira Kenneth John Gollob Maria do Carmo Pereira Nunes Walderez Ornelas Dutra |
| Abstract: | Chagas disease cardiomyopathy is the most severe outcome of the infection with the protozoan Trypano soma cruzi, responsible for over 10,000 deaths annually. There are currently over 100 million people at risk of infection with T. cruzi and, of those, at least 30% may develop the deadly cardiomyopathy. There is no vaccine to prevent the disease and no markers to identify indi viduals at risk of developing the severe form. The great clinical variability of chronic Chagas disease is directly associated with the host’s immune response.(1,2) Research from our group has previously shown that CD14+ monocytes are critical cells in determining the inflammatory and anti-inflammatory immunological profile observed in chronic cardiac and asymptomatic (indeterminate) Chagas patients, respectively.(1) In addition, T. cruzi strains have been associated with severe and mild infections and profoundly affect the response of CD14+ monocytes, inducing an inflammatory or regula tory profile in these cells, respectively. |
| Subject: | Chagas cardiomyopathy Lipopolysaccharide Receptors |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE MORFOLOGIA MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | 10.1590/0074-02760200110 |
| URI: | http://hdl.handle.net/1843/62555 |
| Issue Date: | 2020 |
| metadata.dc.url.externa: | doi:10.1590/0074-02760200110 |
| metadata.dc.relation.ispartof: | Memórias do Instituto Oswaldo Cruz |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| CD14 genotype and functional dichotomy of CD14+ and CD14- cells pdfa.pdf | 472.65 kB | Adobe PDF | View/Open |
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