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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/62645
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dc.creatorEdilamar Silva de Alecrinpt_BR
dc.creatorAna Laura Grossi de Oliveirapt_BR
dc.creatorNathalia Sernizon-guimarãespt_BR
dc.creatorSandra Lyonpt_BR
dc.creatorMaria Auxiliadora Parreiraspt_BR
dc.creatorManoel Otávio da Costa Rochapt_BR
dc.date.accessioned2024-01-11T19:29:42Z-
dc.date.available2024-01-11T19:29:42Z-
dc.date.issued2022-
dc.citation.volume64pt_BR
dc.citation.issuee55pt_BR
dc.citation.spage1pt_BR
dc.citation.epage13pt_BR
dc.identifier.doi10.48331/scielodata.34HR6Ipt_BR
dc.identifier.issn16789946pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/62645-
dc.description.resumoPeople who interact with leprosy patients in their environment, neighborhood, family, or social relationships are at risk to develop the disease. This systematic review investigated the risk and protective factors associated with the development of leprosy in Brazilian contacts. The studies were found in Cochrane Library, PubMed (MEDLINE), Embase, Virtual Health Library, grey literature and hand search until July 2021. The study selection, data extraction and quality assessment were independently performed by two investigators. The quality assessment was performed using the Newcastle-Ottawa Scale (NOS). This review was registered in PROSPERO (CRD42020160680). Seventeen articles fulfilled the inclusion criteria (n=544). The immunological and molecular factors, such as Anti-phenolic Glycolipid Antibodies (Anti PGL-1) seropositivity, negative Mitsuda test, absence of Bacillus Calmette-Guérin (BCG) scar, positive Polymerase Chain Reaction (PCR) in blood; age and race; conviviality, education, contact time and type of contact, as well as elements related to the index case (bacilloscopic index; genetic conditions, family relationships), and some combined factors were shown to be relevant risk factors associated with the development of the disease in Brazilian leprosy contacts. The protective factors reported were the presence of one or more BCG scars, positive Mitsuda test, and education level. All selected studies were considered of high quality according to NOS. The knowledge of disease-related risk and protective factors provides the scientific basis for decision-making in the management of the disease in leprosy contactpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMEDICINA - FACULDADE DE MEDICINApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofRevista do Instituto de Medicina Tropical de São Paulo-
dc.rightsAcesso Abertopt_BR
dc.subjectLeprosypt_BR
dc.subjectRisk factorspt_BR
dc.subjectProtective Factorspt_BR
dc.subjectPublic Health Surveillancept_BR
dc.subjectSystematic Reviewpt_BR
dc.subject.otherLeprosypt_BR
dc.subject.otherRisk factorspt_BR
dc.subject.otherProtective Factorspt_BR
dc.subject.otherPublic Health Surveillancept_BR
dc.subject.otherSystematic Reviewpt_BR
dc.titleFactors associated with the development of leprosy in brazilian contacts: a systematic reviewpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://doi.org/10.1590/S1678-9946202264055pt_BR
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