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http://hdl.handle.net/1843/62661| Tipo: | Artigo de Periódico |
| Título: | Hepatitis c in the brazilian public health care system: burden of disease |
| Autor(es): | Adautocastelo Paulo Roberto Abrão Ferreira Carlos Eduardo Brandão Mello Rosangela Teixeira Jose Valdez Ramalho Madruga Tania Reuter Leila Maria Moreira Beltrão Pereira Giovanni Faria Silva Mario Reis Álvares-da-silva Heverton Zambrini |
| Resumo: | Background – Infection by hepatitis C virus is one of the leading causes of chronic hepatitis C and cause severe burden for patients, families and the health care system. Objective – The aims of this research were to assess the severity of liver fibrosis, comorbidities and complications of hepatitis C virus; to examine health-related quality of life (HRQoL), productivity loss and resource use and costs in a sample of Brazilian chronic hepatitis C, genotype 1, patients. Methods – This was a cross-sectional multicenter study performed in genotype-1 chronic hepatitis C patients to assess disease burden in the Brazilian public health care system between November 2014 and March 2015. Patients were submitted to a liver transient elastography (FibroScan) to assess liver fibrosis and answered an interview composed by a questionnaire specifically developed for the study and three standardized questionnaires: EQ-5D-3L, HCV-PRO and WPAI:HepC. Results – There were 313 subjects enrolled, with predominance of women (50.8%), caucasian/white (55.9%) and employed individuals (39.9%). Mean age was 56 (SD=10.4) years old. Moreover, 42.8% of patients who underwent FibroScan were cirrhotic; the most frequent comorbidity was cardiovascular disease (62.6%) and the most frequent complication was esophageal varices (54.5%). The results also showed that “pain and discomfort” was the most affected HRQoL dimension (55.0% of patients reported some problems) and that the mean HCV-PRO overall score was 69.1 (SD=24.2). Regarding productivity loss, the most affected WPAI:HepC component was daily activity (23.5%) and among employed patients, presenteeism was more frequent than absenteeism (18.5% vs 6.5%). The direct medical costs in this chronic hepatitis C sample was 12,305.72USD per patient in the 2 years study period; drug treatment costs represented 95.9% of this total. Conclusion – This study showed that most patients are cirrhotic, present high prevalence of cardiometabolic diseases and esophageal varices, reducedHRQoL mainly in terms of pain/discomfort, and work productivity impairment, especially presenteeism. Additionally, we demonstrated that hepatitis C virus imposes an economic burden on Brazilian Health Care System and that most of this cost is due to drug treatmen. |
| Assunto: | Hepatitis C Liver Cirrhosis Quality of life. Cost of Illness |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
| Tipo de Acesso: | Acesso Aberto |
| Identificador DOI: | 10.1590/s0004-2803.201800000-74 |
| URI: | http://hdl.handle.net/1843/62661 |
| Data do documento: | 2018 |
| metadata.dc.url.externa: | https://doi.org/10.1590/S0004-2803.201800000-74 |
| metadata.dc.relation.ispartof: | Arquivos de Gastroenterologia |
| Aparece nas coleções: | Artigo de Periódico |
Arquivos associados a este item:
| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Hepatitis C in the Brazilian public health care pdfa.pdf | 183.95 kB | Adobe PDF | Visualizar/Abrir |
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